摘要
十余年前奇士肽(Kisspeptin)的发现已成为人类生殖功能调控的新里程碑,更新了神经内分泌调控生殖功能的认识。奇士肽神经元联动兴奋性神经激肽B和抑制性强啡肽神经元形成KNDy网络,从上游调控GnRH的脉冲分泌和下丘脑-垂体-性腺轴功能。KNDy神经元应答性激素的负反馈和正反馈信号、介导青春期启动和在下丘脑神经内分泌网络反映身体能量代谢状态方面起关键性作用。
The discovery of kisspeptin became a new milestone in the regulation of human reproduction more than a decade ago,and it updated awareness of the neuroendocrine regulation of reproductive function.Kisspeptin neurons which synchronize with stimulatory signal from neurokinin B and inhibitory signal from dynorphin neurons to form the KNDy network have been identified to act upstream of GnRH neurons to control GnRH pulsatile secretion and the function of the hypothalamicpituitary-gonadal axis.KNDy neurons response to both negative and positive feedback signals of sex steroids and mediate the onset of puberty,which plays a pivotal role in connection between hypothalamic neuroendocrine network and energy metabolism of the body.
出处
《生殖医学杂志》
CAS
2017年第2期99-105,共7页
Journal of Reproductive Medicine
关键词
奇士肽
神经内分泌网络
调控
生殖功能
Kisspeptin
Nneuroendocrine network
Regulation
Reproductive function
