摘要
目的:观察苓玉清络饮对无症状高尿酸血症患者血清尿酸(UA)、超敏-C反应蛋白(hs-CRP)及血脂的影响。方法:将60例无症状高尿酸血症患者随机分为对照组、观察组各30例。对照组仅予以健康教育、低嘌呤饮食等基础措施治疗1个月。观察组在对照组基础上口服苓玉清络饮颗粒剂,每日1剂,早晚分服,治疗1个月。观察两组患者治疗前后血清UA、hsCRP、甘油三酯(TG)、胆固醇(TC)水平及血常规、肝肾功能等安全性指标有无变化。结果:治疗前两组患者血清UA、hsCRP、TG及TC水平差异均无统计学意义(P>0.05)。治疗后,观察组与对照组血清UA、TC水平较治疗前均有所下降(P<0.05或P<0.01),且前者较后者下降更明显,差异有统计学意义(P<0.01);观察组hs-CRP、TG水平较治疗前明显下降,差异有统计学意义(P<0.01),对照组hs-CRP及TG水平治疗前后未有明显变化(P>0.05)。两组患者治疗后血常规、肝肾功能各指标与治疗前比较,差异均无统计学意义(P>0.05)。结论:苓玉清络饮不仅能明显降低无症状高尿酸血症患者血清UA,还可降低hs-CRP、TG及TC水平,减轻患者的炎症反应,改善脂质代谢紊乱,降低高尿酸血症患者的心血管风险,预期临床疗效及安全性较好,值得临床长期应用。
Objective： To observe the effect on the serum uric acid（ UA）,hypersensitivity- C- reactive protein（ hs- CRP） and blood lipids of patients with asymptomatic hyperuricemia by Lingyu Qingluo Decoction. Methods： 60 patients with asymptomatic hyperuricemia were randomly divided into control group and observation group each with 30 patients. The control group only received healthly education,low- purine diet and other basic measures for one month. On the basis of the control group,the observation group had perred os Lingyu Qingluo Decoction granules,one day a dose,treating for one month. Observing two groups of patients’ levels of serum UA,hs-CRP,triglyceride（ TG）,cholesterol（ TC） and safety indexes such as routine blood test,liver and kidney function have any changes be-fore and after treatment. Results： Two groups of patients’ levels of serum UA,hs- CRP,TG and TC were not significantly different（ P 〉0. 05）. After treatment,the observation group’s and the control group’s levels of serum UA,TC were decreased compared with the previous（ P 〈 0. 05 or P 〈 0. 01）,and the former decreased more significantly than the latter,which difference was statistically significant（ P〈 0. 01）; The observation group’s levels of hs- CRP,TG were significantly decreased than before treatment,which difference was statistically significant（ P 〈 0. 01）,the control group’s levels of hs- CRP and TG didn’t have any significant changes（ P 〉 0. 05）. After treatment the two groups patients’ safety indexes such as routine blood test,liver and kidney function were compared with before treatment,the differences were not statistically significant（ P 〉 0. 05）. Conclusion： Not only could Lingyu Qingluo Decoction reduce asymptomatic hyperuricemia patients’ serum UA,but also reduce the levels of hs- CRP,TG and TC,reducing patients’ inflammatory response,improving lipid metabolic disorder,reducing cardiovascular risk in hyperuricemia patients,the expected clinical efficacy and safety are very good,worthy of long- term clinical applications.
出处
《江西中医药大学学报》
2017年第1期61-63,93,共4页
Journal of Jiangxi University of Chinese Medicine
