摘要
目的分析低T_3水平与急性脑梗死临床严重程度及预后的关系。方法选取神经内科病房收治的急性脑梗死患者119例,根据入院时简易精神状态评分量表(MMSE)评分分为轻、中、重组,对比3组游离T_3(FT3)、游离T4(FT4)和促甲状腺激素(TSH)水平。根据T_3水平分为低T_3亚组和T_3正常亚组,比较2组入院时及出院后30 d美国国立卫生研究院卒中量表(NIHSS)和改良Rankin量表(mRS)评分。结果轻组、中组、重组FT3水平比较差异有统计学意义(P<0.05),3组FT4和TSH水平比较差异均无统计学意义(P>0.05)。低T_3亚组入院时NIHSS评分和治疗30 d后NIHSS评分均高于正常T_3亚组,△NIHSS≥2患者所占比率低于正常T_3亚组,差异均有统计学意义(P<0.01);低T_3亚组mRS评分高于正常T_3亚组,mRS≤1患者所占比率低于正常T_3亚组,差异均有统计学意义(P<0.05)。结论急性脑梗死合并低T_3综合征较常见,且低T_3状态与严重的神经功能缺损及预后相关。
Objective To analysis the relationship of low T_3 level and the clinical severity and prognosis of acute cerebral infarction patients. Methods Selected 119 cases patients with acute cerebral infarction in the hospital neurology ward. 119 cases patiens with acute cerebral infarction were divided into light group,middle group and recombinant group according to MMSE score,compared the level of FT_3,FT4,TSH in 3 groups. 119 cases patients were divided into low T_3 group and T_3 normal group,and compared the NIHSS and mRS score of 2 groups. Results The level of FT_3 among light group,middle group,recombination group was statistic significantly（ P〈0. 05）. The level of FT4 and TSH among light group,middle group,recombination group was no statistic significantly（ P〉0. 05）. The level of NIHSS score on admission and 30 d after treatment of low T_3 group were higher than that of normal T_3 group,The △NIHSS≥2 ratio of low T_3 group was lower than that of normal T_3 group,the difference was statistic significantly（ P 〈0. 01）. The mRS score of low T_3 group was higher than that of normal T_3 group,the mRS≤1 ratio was lower than that of normal T_3 group,the difference was statistic significantly（ P〈0. 05）. Conclusion Acute cerebral infarction merge with low T_3 syndrome is common,and the status of T_3 is closely to the severe neurological deficit and prognosis.
出处
《临床合理用药杂志》
2017年第7期16-17,共2页
Chinese Journal of Clinical Rational Drug Use
