摘要
目的对比老年帕金森伴精神障碍患者使用氟哌啶醇与利培酮治疗的疗效。方法 100例老年帕金森伴精神障碍患者,随机分为对照组与观察组,各50例。观察组患者给予氟哌啶醇治疗,对照组患者给予利培酮治疗。对治疗前后运动功能、精神抑郁、认知能力以及精神障碍程度进行评价,同时比较用药不良反应发生情况。结果治疗后,两组患者的阳性和阴性症状量表(PANSS)评分、简易精神状态量表(MMSE)评分、汉密尔顿抑郁量表(HAMD)评分、统一帕金森病评分分量表(UPDRS)评分均较治疗前改善,差异均具有统计学意义(P<0.05);组间治疗后比较,观察组PANSS评分及MMSE评分优于对照组,差异均具有统计学意义(P<0.05),两组HAMD评分及UPDRS评分比较,差异均无统计学意义(P>0.05)。观察组不良反应发生率为12.0%,对照组不良反应发生率为18.0%,比较差异无统计学意义(P>0.05)。结论运用氟哌啶醇治疗对老年帕金森伴精神障碍患者的精神障碍以及认知能力改善较利培酮有显著的优势。
Objective To compare the curative effect of elderly Parkinson＇s disease complicated with mental disorders treated with risperidone and haloperidol. Methods A total of 100 elderly Parkinson＇s disease complicated with mental disorders patients were randomly divided into control group and observation group, with 50 cases in each group. The observation group received haloperidol for treatment, and the control group received risperidone for treatment. Evaluation were made on movement function, deprementia, cognitive and psychiatric disorders degree before and after treatment, and occurrence of drug adverse reactions was compared in two groups. Results After treatment, both groups had better positive and negative symptoms scale（PANSS） score, minimental state evaluation（MMSE） score, Hamilton depression scale（HAMD） score, unified Parkinson＇s disease rating scale（UPDRS） score than before treatment, and the difference had statistical significance（P〈0.05）. After treatment, the observation group had better PANSS score and MMSE score than the control group, and the difference had statistical significance（P〈0.05）. Both groups had no statistically significant difference in HAMD and UPDRS score（P〉0.05）. The observation group had incidence of adverse reactions as 12.0%, while the control group had incidence of adverse reactions as 18.0%, and the difference had no statistical significance（P〉0.05）. Conclusion Implement of haloperidol has significant advantages in mental disorders and cognitive ability improvement than risperidone for the treatment of elderly Parkinson＇s disease complicated with mental disorders patients.
作者
李巍
LI Wei(Ward Two, Shenyang City Mental Health Center, Shenyang 110168, China)
出处
《中国实用医药》
2017年第6期92-94,共3页
China Practical Medicine
关键词
老年帕金森
精神障碍
利培酮
氟哌啶醇
Elderly Parkinson＇s disease
Mental disorders
Risperidone
Haloperidol
