摘要
目的观察长春西汀对急性缺血性卒中后认知障碍的影响。方法 58例急性缺血性卒中后认知障碍患者随机分为治疗组和对照组,每组29例。治疗组使用长春西汀静脉滴注治疗,对照组给予胞磷胆碱钠静脉滴注治疗,对两组治疗前及治疗后21 d蒙特利尔认知评估量表(MoCA)及生活能力评分进行比较,并观察不良反应发生情况。结果治疗前两组MoCA、生活能力评分比较,差异无统计学意义(P>0.05)。治疗后,治疗组MoCA评分(24.72±2.46)分、生活能力评分(66.28±5.11)分均明显优于治疗前,且优于对照组的(18.34±2.57)、(45.03±4.95)分,差异均具有统计学意义(P<0.05)。两组均无严重不良反应发生。结论长春西汀对急性缺血性卒中后认知障碍患者的认知功能及日常生活能力改善有显著作用。
Objective To observe influence by vinpocetine on post acute ischemic stroke cognitive impairment. Methods A total of 58 patients with post acute ischemic stroke cognitive impairment were randomly divided into treatment group and control group, with 29 cases in each group. The treatment group received vinpocetine through intravenous drop for treatment, and the control group received citicoline sodium through intravenous drop for treatment. Comparison was made on Montreal cognitive assessment（MoCA） and activities of daily living scores between the two groups before and after 21 d of treatment, and occurrence of adverse reactions were observed. Results There was no statistically significant difference of MoCA and activities of daily living scores between the two groups before treatment（P〉0.05）. After treatment, the treatment group had MoCA score as（24.72±2.46） points and activities of daily living score as（66.28±5.11） points, which were obviously better than（18.34±2.57） and（45.03±4.95） points in the control group, and their differences all had statistical significance（P〈0.05）. No serious adverse reations occurred in both two groups. Conclusion Vinpocetine shows remarkable effect in improving cognitive function and activities of daily living of patients with post acute ischemic stroke cognitive impairment.
作者
沈玉梅
SHEN Yu-mei(Department of Neurology, Siping City Fourth People＇s Hospital, Siping 136000, China)
出处
《中国实用医药》
2017年第6期98-99,共2页
China Practical Medicine
关键词
长春西汀
急性缺血性卒中
认知障碍
认知功能
Vinpocetine
Post acute ischemic stroke cognitive impairment
Cognitive function
