摘要
目的:观察止痛化癥胶囊联合抗生素治疗慢性盆腔炎气虚血瘀证的临床疗效。方法:将119例慢性盆腔炎气虚血瘀证患者纳入研究,按照随机数字表法分为对照组59例和观察组60例。对照组采用头孢曲松钠及替硝唑注射液治疗,观察组在对照组用药基础上加服止痛化癥胶囊。2组均用药14天。比较2组治疗前后症状积分、血液流变学指标[纤维蛋白原(Fib)、血浆黏度、全血黏度低切、全血黏度高切]及肿瘤坏死因子-α(TNF-α)、C-反应蛋白(CRP)水平的变化,观察2组临床疗效。结果:治疗后,2组下腹痛、腰骶痛、经量多及带下量多积分均较治疗前下降(P<0.05);观察组的4项症状积分均低于对照组(P<0.05)。治疗后,2组Fib、血浆黏度、全血黏度低切、全血黏度高切及CRP、TNF-α水平均较治疗前下降(P<0.05);观察组的4项血液流变学指标及CRP、TNF-α水平均较对照组下降更显著(P<0.05)。观察组总有效率95.00%,对照组总有效率79.66%,2组比较,差异有统计学意义(P<0.05)。结论:止痛化癥胶囊联合抗生素治疗慢性盆腔炎气虚血瘀证,能更有效地改善患者的症状、血液流变学指标及CRP、TNF-α水平,治疗效果优于抗生素。
Objective：To observe the clinical effect of Zhitong Huazheng capsules combined with antibiotics in treating chronic pelvic inflammation of qi deficiency and blood stasis syndrome.Methods：One-hundred and nineteen cases of patients with chronic pelvic inflammation of qi deficiency and blood stasis syndrome were brought into the study,and were divided into the control group of 59 cases and the observation group of 60 cases randomly.Both groups were treated with the anti-infection treatment of intravenous injection of ceftriaxone sodium and tinidazole,while the observation group was additionally treated with Zhitong Huazheng capsules orally.Both groups received treatment for 14 days.Compared symptom scores,changes of hemorheology indexes[fibrinogen（Fib）,plasma viscosity,whole blood viscosity in low shear rate and whole blood viscosity in high shear rate],tumor necrosis factor-α（TNF-α） and C-reactive Protein（CRP） in both groups before and after treatment,and observed the clinical effect in two groups.Results：After treatment,scores of hypogastralgia,lumbosacral pain,menorrhagia and leukorrhea in both groups were decreased,comparing with those before treatment（P〈0.05）,four symptom scores in the observation group were all lower than those in the control group（P〈0.05）.After treatment,levels of fibrinogen（Fib）,plasma viscosity,whole blood viscosity in low shear rate,whole blood viscosity in high shear rate,CRP and TNF-α in both groups were declined when compared with those before treatment（P〈0.05）.The decrease of four hemorheology indexes and levels of CRP and TNF-α were more obvious in the observation group,comparing with those in the control group（P〈0.05）.The total effective rate was 95.00%in the observation group,and was79.66%in the control group,the difference being significant（P〈0.05）.Conclusion：The therapy of Zhitong Huazheng capsules combined with antibiotics for chronic pelvic inflammation of qi deficiency and blood stasis syndrome can effectively improve symptoms,hemorheology indexes and levels of CRP and TNF-α of the patients,which has better curative effect than that of antibiotics.
出处
《新中医》
CAS
2017年第4期97-100,共4页
New Chinese Medicine
关键词
慢性盆腔炎
气虚血瘀证
中西医结合疗法
止痛化癥胶囊
抗生素
血液流变学
C-反应蛋白(CRP)
肿瘤坏死因子-α(TNF-α)
Chronic pelvic inflammation
Qi deficiency and blood stasis syndrome
Integrate Chinese and western medicine theory
Zhitong Huazheng capsules
Antibiotics
Hemorheology
C-reactive Protein（CRP）
Tumor necrosis factor-α（TNF-α）
