摘要
目的探讨血清尿素氮(BUN)、肌酐(Cr)、胱抑素C(Cy8C)和视黄醇结合蛋白(RBP)四项生化指标联合检测对狼疮肾炎(LN)的早期诊断价值。方法选择2011年1月~2016年4月陕西省人民医院收治并符合美国风湿病协会(ACR)2012年修订的SLE诊断标准并伴有肾脏病变的177例LN患者,同时选择167例健康体检者作为对照组。采用日立7170A全自动生化分析仪对两组血清BUN,Cr,CysC:和RBP浓度进行检测,所得数据用SPSS17.0统计软件进行统计分析。结果 LN患者组与健康对照组比较,血清BUN(6.67±1.43 mmol/L vs 6.57±1.16 mmol/L),Cr(96.9±10.1/μmol/L vs 92.6±13.2μmol/L),CysC(1.7±0.5 mg/L vs 0.75±0.15mg/L),RBP(180.5±8.28 mg/L vs 42.6±9.6 mg/L)浓度均升高,且血清CysC,RBP升高水平与健康对照组比较差异有统计学意义(t=8.145,21.594,均P<0.05)。单项指标检测异常率方面,LN患者组血清BUN,Cr,CysC和RBP的异常率分别为28.3%,29.4%,68.4%和65.0%。四项指标联合检测异常率为85.3%,明显高于单项指标检测异常率(x^2=35.973~168.742,P<0.01)。结论血清BUN,Cr,CysC和RBP四项生化指标联合检测对LN患者肾损伤的早期诊断具有重要意义。
Objective To research the serum urea nitrogen （BUN）,creatinine （Cr）, urinary inhibition C （CysC） and retinol binding protein （RBP） four biochemical indicators of joint detection on the early diagnostic value of lupus nephritis （LN）. Methods According to the American Rheumatology Association （ACR） 2012 revision of the diagnostic criteria, collected 177 LN patients with kidney disease from January 2011 to April 2016 in Shaanxi Provincial People＇s Hospital, at the same time, choose 167 cases of healthy physical examination as normal control group. With Hitachi 7170A a fully automated analy- zer on two groups of serum BUN,Cr,CysC and concentration of RBP for testing, the data obtained by SPSS17.0 statistical software for statistical analysis. Results LN patient group compared with healthy controls,the serum BUN （6.67＋ 1.43 mmol/L vs 6.57＋1.16 mmol/L） ,Cr （96.9＋10.1μmol/L vs 92.6＋13.2 μmol/L） ,CysC （1.7＋0.5 mg/L vs 0.75＋0. 15 mg/L） ,RBP （180, 5＋ 8. 28 mg/L vs 42.6＋ 9.6 rag/L） concentrations were higher, and serum CysC, RBP higher level com- pared with healthy control group difference was statistically significant （t= 8. 145,21. 594, all P〈0.05）. Single parameter detected abnormal rate in terms of LN patients serum BUN, Cr, CysC and RBP abnormal rates were 28.3%, 29.4%, 68.4 %, 65.0 %, four indicators combined detection of abnormal rate was 85.3 %, significantly higher than the single parame ter test （x^2=35. 973~168. 742,al1 P〈0.01）. Conclusion Conhined detection of BUN,Cr,CysC and RBP four early diag- nosis of renal damage in patients with lupus nephritis had important clinical value.
出处
《现代检验医学杂志》
CAS
2017年第2期114-116,共3页
Journal of Modern Laboratory Medicine
基金
西安市科技局科学发展计划项目
编号2016046SF/YX02(3)
关键词
狼疮肾炎
尿素氮
肌酐
胱抑素C
视黄醇结合蛋白
联合检测
lupus nephritis
urea nitrogen
creatinine
urinary inhibition C
retinol binding protein
combined detection
