摘要
目的考察聚乙二醇400(PEG400)对黄芩苷在大鼠体内药动学的影响。方法将大鼠随机分为黄芩苷组和PEG400组,黄芩苷组大鼠单独灌胃给予黄芩苷,PEG400组的灌胃给予黄芩苷和PEG400混合物,于不同时间点取静脉血,用HPLC法检测血浆中的黄芩苷,绘制药时曲线,用DAS 2.0计算药动学参数。结果黄芩苷的线性范围为0.3203~10.25μg·mL^(-1),定量下限为0.3203μg·mL^(-1),日内、日间RSD均<10%,提取回收率>85%,PEG400组的AUC_(0-t)明显高于黄芩苷组。结论 PEG400可促进黄芩苷在大鼠体内的吸收。
OBJECTIVE To ivestigate the effect of polyethylene glycol 400 （PEG400） on the pharmacokinetics of baicalin in rats. METHODS The rats were randomly divided into baicalin group and polyethylene glycol 400 group. Concentration of baicalin in plasma was contented at the different time by HPLC, the concentration - time curve was created, and pharmacokinetie parameters were calculated by DAS 2.0. RESULTS The linear range of baicalin was 0. 3203 - 10.25 μg mL-i, lower limit of quantification was 0. 3203 μg mL-1 ,RSD were less than 10%. Extraction recovery were 〉 85%. AUC0-1 from PEG 400 was significantly higher than that of the baicalin group. CONCLUSION PEG400 can enhance the bioavailability of baicalin in the rats.
出处
《华西药学杂志》
CAS
CSCD
2017年第2期132-134,共3页
West China Journal of Pharmaceutical Sciences
基金
国家自然科学基金资助项目(批准号:81160413)
微生物与生化药学工程研究中心项目(黔教合KY字[2015]338)
贵州省科技厅项目(黔科合成转字[2015]5213号)
关键词
聚乙二醇400
黄芩苷
体内
药动学
Polyethylene glycol 400
Baicalin
In vivo
Pharmacokinetics
