摘要
目的:探讨葛根素注射液治疗老年女性骨质疏松症合并不稳定型心绞痛的疗效和安全性,及对血清炎症因子的影响。方法:回顾性分析107例老年女性骨质疏松症合并不稳定型心绞痛患者资料,按用药的不同分为对照组(53例)和观察组(54例)。对照组患者给予钙尔奇D片、阿仑膦酸钠片、硝酸甘油片、酒石酸美托洛尔片、阿托伐他汀钙片、盐酸曲美他嗪片等常规治疗。观察组患者在对照组治疗的基础上给予葛根素注射液4 m L,加入5%葡萄糖注射液500 m L中,静脉滴注,每日1次。两组疗程均为2周。观察两组患者的临床疗效,治疗前后血清炎症因子[超敏C反应蛋白(hs-CRP)、肿瘤坏死因子α(TNF-α)、基质金属蛋白酶-9(MMP-9)、可溶性白细胞分化抗原40配体(sCD40L)]水平及不良反应发生情况。结果:观察组患者心绞痛总有效率、骨质疏松症骨痛总有效率均显著高于对照组,差异均有统计学意义(P<0.05)。治疗前,两组患者hs-CRP、TNF-α、MMP-9和sCD40L水平比较,差异均无统计学意义(P>0.05)。治疗后,两组患者hs-CRP、TNF-α、MMP-9和sCD40L水平均显著低于同组治疗前,且观察组显著低于对照组,差异均有统计学意义(P<0.05)。两组患者治疗期间均未见明显不良反应发生。结论:在常规治疗的基础上,葛根素注射液治疗老年女性骨质疏松症合并不稳定型心绞痛的疗效显著,能显著降低血清炎症因子水平,且安全性较好。
OBJECTIVE： To explore therapeutic efficacy and safety of Puerarin injection for elderly female patients with osteoporosis and unstable angina pectoris, and its effects on serum inflammatory factors. METHODS： Totally 107 elderly women with osteoporosis and unstable angina were analyzed retrospectively and divided into control group （53 cases） and observation group （54 cases） according to drug use. Control group was given routine treatment as Caltrate D, Alendronate sodium tablet, Glyceryl trinitrate tablet ,Metoprolol tartrate tablet,Atorvastatin calcium tablet, Trimetazidine hydrochloride tablet. On the basis of control group, observation group was additionally given Puerarin injection 4 mL added into 5% Glucose injection 500 mL intravenously, once a day. Treatment course of 2 groups lasted for 2 weeks. Therapeutic efficacies of 2 groups were observed as well as the levels of serum inflammatory factors （hs-CRP, TNF-α, MMP-9, sCD40L）, and the occurrence of ADR. RESULTS： The total response rates of angina pectoris and osteoporosis pain in observation group were significantly higher than control group, with statistical signifi- cance （P〈0.05）. Before treatment, there was no statistical significance in serum inflammatory factors as hs-CRP, TNF-α, MMP-9, sCD40L between 2 groups （P〉0.05）. After treatment, the levels of hs-CRP, TNF-a, MMP-9 and sCD40L in 2 groups were significantly lower than before, and the observation group was significantly lower than the control group, with statistical sig- nificance （P〈0.05）. No obvious ADR was found in 2 groups during treatment. CONCLUSIONS： Based on routine treatment, Pu- erarin injection shows significant therapeutic efficacy for senile female osteoporosis patients with unstable angina and can significant- ly reduce the levels of serum inflammatory factors with good safety.
出处
《中国药房》
CAS
北大核心
2017年第12期1644-1647,共4页
China Pharmacy
关键词
葛根素注射液
骨质疏松症
不稳定型心绞痛
疗效
安全性
炎症因子
Puerarin injection
Osteoporosis
Unstable angina pectoris
Therapeutic efficacy
Safety
Inflammatory factors
