摘要
鬼针草是一味具有广泛药效学作用的临床常用中药,除具有较好的降血压、免疫调节、抗炎、抗纤维化、抗氧化等作用外,也表现出较好的抗肿瘤作用,然而现阶段对其抗癌活性成分的筛选还不够全面,其复方制剂中鬼针草的具体药理作用机制还需进一步研究。鬼针草主要活性组分为黄酮类成分,组分中各化合物之间相互作用、相互影响,致使组分的代谢组学研究相对滞后。随着中药化学成分分析技术的发展,药物代谢酶、代谢基因多态性等细胞分子学研究更为深入,该研究过程既是促进药物的临床合理应用,也促进了中药发展现代化、国际化,相信鬼针草的药效学研究可以作为一个长远的中医药药效探索发展方向,以便使其多方面的药用价值得以开发。
Sticktight is clinical commonly used Chinese medicine with broad pharmacodynamic action,besides having good blood pressure,immune regulation,anti inflammation,anti fibrosis,antioxidation,also performance of good antitumor effect,but the screening of its anticancer active ingredients is not comprehensive enough,and specific pharmacological mechanism of Sticktight in compound preparations still need to be intensively studied.The main active component of Sticktight is flavonoids,interaction and mutual influence between the components in the compound,resulting in metabonomics research lagging behind.With the development of technology of chemical components of traditional Chinese medicine,more deeply research on drug metabolizing enzymes,metabolism of polymorphism and molecular cell.This study is not only promotion the clinical rational use of drugs,but also promotion the development of Chinese medicine modernization,internationalization.It is believed that the pharmacodynamics study of Sticktight can be used as a traditional Chinese medicine long-term exploration and development direction,in order to make the various medicinal values to be developed.
出处
《中医学报》
CAS
2017年第4期610-612,共3页
Acta Chinese Medicine
基金
河南省科技攻关项目(162102310064)
关键词
鬼针草
总黄酮
药效学
中药
Sticktight
total flavonoids
pharmacodynamics
Chinese medicine
