摘要
目的研究复方甘草酸苷治疗慢性乙型肝炎的临床可行性。方法方便选取该院2015年10月—2016年10月诊治的慢性乙型肝炎患者120例,随机分两组,对照组和研究组各有60例。对照组进行常规西药治疗,采用的药物是甘草酸二铵,研究组采用复方甘草酸苷治疗。比较两组患者慢性乙型肝炎治疗总有效率;药物治疗后不良反应现象;施行治疗前和施行治疗后患者肝功能相关指标的差异。结果研究组患者慢性乙型肝炎治疗总有效率96.67%高于对照组83.33%(P<0.05);研究组药物治疗后不良反应发生率5.00%与对照组3.33%比较差异无统计学意义(P>0.05),其中,对照组有1例轻度血压升高、1例下肢水肿,研究组患者有1例轻度血压升高、1例下肢水肿,1例恶心;施行治疗前两组肝功能相关指标比较差异无统计学意义(P>0.05);施行治疗后研究组肝功能相关指标改善幅度更大(P<0.05)。结论复方甘草酸苷治疗慢性乙型肝炎的临床可行性高,可有效改善患者肝功能,无严重用药不良反应,安全性高,可推广应用。
Objective To research the feasibility of compound glycyrrhizin in treatment of chronic hepatitis B. Methods Convenient selection 120 cases of patients with chronic hepatitis B treated in our hospital from October 2015 to October2016 were randomly divided into two groups with 60 cases in each, the control group adopted the routine western medicine of diammonium glycyrrhizinate, while the research group adopted the compound glycyrrhizin, and the total treatment effective rate, adverse reactions after drug treatment and liver function related indexes before and after treatment were compared between the two groups. Results The total treatment effective rate of chronic hepatitis B in the research group was higher than that in the control group(96.67% vs 83.33%), and the difference in the incidence rate of adverse reactions between the research group and the control group had no statistical significance(5.00% vs 3.33%), and in the control group, 1 case with mild increase of blood hypertension and 1 case with eema of lower extremity, in the research group, there was 1 case with mild blood pressure increase, 1 case with eema of lower extremity and 1 case with nausea, and before treatment, the differences in the related liver function related indicators between the two groups had no statistical significance(P>0.05), and the after treatment, the liver function related indicators improvement range was bigger(P<0.05). Conclusion The clinical feasibility of compound glycyrrhizin in treatment of chronic hepatitis B is high, which can effectively improve the liver function of patients without severe medication adverse reactions, and the safety is high, which can be promoted and applied.
出处
《中外医疗》
2017年第6期123-124,148,共3页
China & Foreign Medical Treatment
关键词
复方甘草酸苷
慢性乙型肝炎
临床可行性
Compound glycyrrhizin
Chronic hepatitis B
Clinical feasibility
