摘要
近年来糖尿病认知功能障碍作为一种糖尿病中枢神经系统并发症越来越受到人们的重视。糖尿病导致的中枢神经系统并发症常伴随着血脑屏障结构和功能的破坏。血脑屏障是中枢神经系统所特有的结构,对维持大脑内环境稳定以及分子转运起着重要作用。在糖尿病的病理发生发展过程中,高血糖、晚期糖基化终产物、炎性因子等诸多因素均可导致血脑屏障损伤,进而引起脑内神经元受损,从而导致认知功能障碍的发生。稳定血脑屏障可能成为治疗糖尿病认知功能障碍的主要策略之一,对血脑屏障改善糖尿病认知功能障碍以及相关中药的干预作用进行综述。
Recently, diabetic cognitive dysfunction, as one of central nervous system complications caused by diabetes, has attracted the public＇s attention. The central nervous system complications caused by diabetes is associated with the disruption of blood brain barrier （BBB） in structure and function. The BBB, unique to the central nervous system structure, plays a crucial point in maintaining the homeostasis and molecular transport in brain. Many factors such as hyperglycemia, AGEs, and proinflammatory cytokines result in the lesion on blood brain barrier in the process of the development of diabetes. They cause brain neuron dysfunction, and then lead to cognitive dysfunction. Maintaining the BBB homeostasis may be the majority strategy in diabetic cognitive dysfunction treatment. This article reviews the improvement of BBB on diabetic cognitive dysfunction, and the intervention of traditional Chinese medicine.
出处
《现代药物与临床》
CAS
2017年第3期548-552,共5页
Drugs & Clinic
基金
国家自然科学基金资助项目(81403213
81673707)
长江学者和创新团队发展计划资助项目(IRT_14R41)
关键词
糖尿病认知功能障碍
血脑屏障
中枢神经系统
中药
diabetic cognitive dysfunction
blood brain barrier
central nervous system
traditional Chinese medicine
