摘要
目的利用四氯化碳(carbon tetrachloride,CCl4)复制大鼠肝纤维化模型,通过Logistic回归探讨实时剪切波弹性成像(shear wave elastography,SWE)联合血清指标对肝纤维化严重程度的预测能力。方法 40%CCl4复制大鼠肝纤维化模型,超声检测肝组织SWE杨氏模量。全自动分析仪检测血清AST、ALT、ALP、ALB含量。大鼠肝组织HE染色,光镜下判定肝纤维化程度。结果 1)随着大鼠肝纤维化加重,SWE杨氏模量、血清AST、ALT、ALP水平呈上升趋势,ALB呈下降趋势;2)logistic回归分析表明SWE杨氏模量及血清学指标在肝纤维化严重程度判定中均有统计学意义(P<0.05),其中SWE杨氏模量对肝纤维化严重程度判定预测能力最大,R^2值为0.788。SWE杨氏模量联合ALT的预测能力较高,R^2值均为0.821。结论 SWE杨氏模量与血清学指标AST、ALT、ALP、ALB可以预测肝纤维化严重程度。联合SWE杨氏模量与血清学可以有效的提高对肝纤维化严重程度的预测能力。
Objective To investigate the predictive ability of real-time shear wave elastography combined serological index for the severity of CCl4-induced liver fibrosis in rat model by Logistic regression analysis. Methods 40% of CCl4 induced liver fibrosis model in rat, ultrasound detected liver tissue SWE Young＇s modulus. The content of serum AST, ALT, ALP and ALB were detected with automatic analyzer. The degree of hepatic fibrosis was determined under light microscope after HE stained. ReSults 1 ） SWE Young＇s modulus, serum AST, ALT and ALP levels were increased, and the ALB showed a downward trend with the aggravation of hepatic fibrosis in rats ; 2） Logistic regression analysis showed that SWE Young＇s modulus and serological index in judging the severity of liver fibrosis were statistically significant （ P 〈 0.05 ）, in which SWE Young＇s modulus had the largest ability, and the R2 value was 0.788. The prediction ability of Young＇s modulus of SWE combined with ALT was higher, and the R2 value was 0. 821. Conclusion SWE Young;s modulus and serum indexes of AST, ALT, ALP, ALB can predict the severity of liver fibrosis. Combined SWE Young＇s modulus and serum can effectively improve the prediction ability of the severity of liver fibrosis.
出处
《医学影像学杂志》
2017年第4期749-753,788,共6页
Journal of Medical Imaging
