摘要
目前,肥胖与甲状腺癌的发病率在全球范围内均快速增长,严重影响了公众健康及国民生活质量。且肥胖导致的胰岛素抵抗、体内高水平的促甲状腺激素、多种炎性因子及脂肪因子的异常表达、高血糖及高血脂均与甲状腺癌的发生密切相关。甲状腺癌在女性中高发与其雌激素水平有关,且雌激素本身可介导甲状腺癌的发生。而女性不同时期体内雌激素水平的变化又影响其脂肪分布,故使不同时期的女性更易发生肥胖,这也与甲状腺癌的发生密不可分。因此,未来可将肥胖作为临床预防甲状腺癌的新靶点。
At present, the incidence of obesity and thyroid cancer has increased rapidly in the world, which seriously affects the public health and the quality of life of the people. And insulin resistance, high levels of thyroid stimulating hormone, abnormalities of the inflammation and adipokines, hyperglycemia and high blood lipids caused by obesity were closely related to the occurrence of thyroid cancer. The high incidence of thyroid cancer in women is related to the level of estrogen in women. Estrogen itself can mediate the incidence of thyroid cancer, but the changes of women in different periods of estrogen affect the fat distribution, thus women in different periods are more likely to become fat, which is closely connected with the occurrence of thyroid cancer. Therefore, obesity can be used as a new target for the prevention of thyroid cancer.
作者
周悦
闫爽
ZHOU Yue YAN Shuang.(Department of Endocrinology, the Fourth Affiliated Hospital of Harbin Medical University, Harbin 150001, China)
出处
《医学综述》
2017年第8期1520-1523,1528,共5页
Medical Recapitulate
基金
黑龙江省自然科学基金(ZD201319)
