摘要
胶原蛋白是动物体内重要的结构蛋白质,因具有生物可降解性、生物相容性、无毒等特性而被广泛应用。本文综述了戊二醛、β-环糊精聚轮烷单醛、丙二酸等交联剂对胶原蛋白进行化学改性的方法研究现状,并介绍了胶原蛋白改性材料在止血、药物运输载体、组织工程支架等方面应用的研究进展。
Collagen is an important structural protein in animal body. It is widely used because of its biode-gradability ,biocompatibility and nontoxicity. In this paper, the research progress of the chemical modifica-tion of collagen by glutaraldehyde, β - cyclodextrin, polyrotaxane aldehyde, malonic acid and other crosslinking agents was reviewed, and the application of collagen modified materials in hemostatic, drug de-livery carrier and tissue engineering scaffold was introduced.
出处
《渔业研究》
2017年第2期147-156,共10页
Journal of Fisheries Research
基金
基金项目:黄渤海区域主要水产品加工副产物高值化利用产业化关键技术集成及示范(201505030)
关键词
胶原蛋白
化学改性
交联剂
collagen
chemical modification
crosslinking agent
