摘要
目的研究阿托伐他汀对β淀粉样蛋白1-42诱导阿尔茨海默病(Alzheimer’s disease,AD)大鼠模型学习记忆力的影响。方法将20只Wistar大鼠随机分为模型对照组和他汀治疗组,每组10只。水迷宫实验观测各组大鼠的学习记忆力。结果他汀治疗组大鼠的学习记忆力改善,与模型对照组相比差异有统计学意义。结论阿托伐他汀可减轻神经细胞损伤,改善学习和记忆力。
Objective To observe the effect of atorvastatin on rats model learning memory with Alzheimer＇ s disease induced by Clumped beta amyloid protein 1 -42. Methods Twenty Wistar rats were randomly divided into AD model group and statin therapy group, each group consist of ten rats, observe rats learning memory through Water maze experiment. Results AD group learning memory decline and compared with normal control group has a significant statistical difference. Conclusion Atorvastatin may alleviate nerve cell damage and improve the learning ability and memory.
出处
《医药论坛杂志》
2017年第2期16-17,共2页
Journal of Medical Forum
基金
河南省2014年科技发展计划(142102310410)
