摘要
目的 探讨SOX与GP两种联合化疗方法对的治疗疗效与用药后的不良反应。方法 将2014年1月~2016年9月前来山东省医学科学院附属医院接受治疗的晚期三阴性乳腺癌患者84例作为本研究的观察对象,随机分为SOX组与GP组,分别给予相应的化疗措施并观察治疗疗效。结果 2组患者的CR、PR、SD、PD例数及总有效率比较,P值分别为0.693、0.637、0649、0.801、0.823;2组患者腹泻、肝功能损伤、血小板减少、恶心呕吐、神经毒性、贫血、白细胞减少、皮疹、肾毒性、食欲下降发生率比较,P值分别为0.374、0.629、0.643、0.374、0.645、0.434、0.450、0.693、0.645、0.815。结论 晚期三阴性乳腺癌的标准化疗方案虽仍不能统一,但SOX方案与GP方案均安全有效,可用于临床治疗。
Objective To investigate the efficacy and adverse reactions of SOX and GP combined with two chemotherapy methods. Methods F r o m January 2014 to September 2016 came to our hospital for treatment of three advanced breast cancer patients with negative 84 cases as the research object of observation, were randomly divided into SOX group and GP group were given chemotherapy measures and clinical observation on the treatment of. Results Two groups of patients with CR, PR, SD, PD,the number of cases and the total effective rate comparison, P v a l u e s w e r e 0. 6 9 3 , 0. 6 3 7 , 0649, 0.801, 0. 823; two groups of patients with diarrhea, liver damage, thrombocytopenia, nausea and vomiting, neurotoxicity, anemia, leukopenia, rash, renal toxicity, appetite the incidence rate of decline , P values were 0. 374 , 0. 629 , 0. 643 , 0. 374 , 0. 645 , 0. 434 , 0. 450 , 0. 693 , 0. 645 , 0. 815. Conclusion Standard chemotherapy regimens for advanced three negative breast cancer was not uniform, but the SOX and GP regimens are safe and effective, can be used for clinical treatment.
出处
《中国生化药物杂志》
CAS
2017年第4期293-295,共3页
Chinese Journal of Biochemical Pharmaceutics
关键词
奥沙利铂
替吉奥
吉西他滨
顺铂
三阴性乳腺癌
oxaliplatin
tegafur gimeracil oteracil potassium capsule
gemcitabine
cisplatin
triple negative breast cancer
