摘要
目的:分析研究慢性阻塞性肺疾病血清甲状腺素水平变化与疾病严重程度的相关性。方法:选取2013年4月至2015年9月在我院诊治的41例缓解期及123例急性加重期慢性阻塞性肺疾病患者,急性加重期又分为轻度缺氧组(Pa O2>60mm Hg)、中度缺氧组(40mm Hg<PaO_2<60mm Hg)及重度缺氧组(Pa O2<40mm Hg)同时选取同时期在我院常规体检41例健康人,对其血清甲状腺激素水平进行测定研究。结果:健康对照组与缓解期组比较TT3、FT3、TT4、FT4、TSH水平差异无统计学意义(P>0.05),而急性发作期组较其余两组各指标均降低(P<0.05),中度缺氧组较轻度缺氧组TT3、FT3、TT4、FT4、TSH水平下降(P<0.05),重度缺氧组各项指标水平又较中度缺氧组下降(P<0.05),三组间各检测指标水平差异均有统计学意义。结论:慢性阻塞性肺疾病血清甲状腺素水平与病变严重程度呈正相关,随着病变加重其水平异常变化更为明显,临床检测对病变程度判断具有重要意义。
Objective： To analyze serum thyroid hormone level change of chronic obstructive pulmonary disease and the correlation between the severity of disease. Methods： 41 cases of patients with chronic obstructive pulmonary disease in remission and 123 cases in exacerbation（ including PaO2〉60mm Hg,40 mm Hg〈Pa O2〈60mm Hg and PaO2〈40mm Hg group） from April 2013 to September 2015 in our hospital and 41 cases of healthy people by routine check-up in our hospital during the same period were selected,then the serum thyroid hormone levels were determined. Results： Compared with healthy control group,TT3,FT3,TT4,FT4,TSH level in remission group has no statistical difference（ P 〉 0.05）,while compared with the rest of the two groups,all indexes in exacerbation group were significantly lower（ P 〈 0.05）.And TT3,FT3,TT4,FT4,TSH levels in moderate hypoxia group significantly decreased compared with those in relatively mild hypoxia（ P 〈 0.05）. The level of each index in severe hypoxia group significantly decreased compared with the moderate hypoxia group（ P 〈 0. 05）. There was statistical difference in detection index level between three groups. Conclusion： The serum thyroid hormone level of chronic obstructive pulmonary disease is positively correlated with disease severity,level changes are more apparent as the pathological changes,clinical detection is of great significance in lesion severity judgment.
出处
《河北医学》
CAS
2017年第3期421-424,共4页
Hebei Medicine
基金
江门市科技计划项目
(编号:江科(2012)114号)
关键词
慢性阻塞性肺疾病
血清甲状腺素
相关性
Chronic obstructive pulmonary disease
Serum thyroid hormone
Correlation
