摘要
目的探讨乳腺癌患者术后小腿肌间静脉血栓形成（CMVT）的发生率及危险因素。方法回顾性分析2012年1月至2013年11月山东大学齐鲁医院行乳腺癌手术的临床资料，根据术后有无出现小腿肌间静脉血栓分组，分析患者一般临床特点及相关的实验室检查结果和抗肿瘤治疗。结果患者的年龄≥45岁、合并高血压、冠心病、APTT〈30．85s是乳腺癌术CMVT的危险因素。将4个危险因素进行二元logistic回归分析，乳腺癌术后cMVT的独立危险因素是年龄≥45岁和APTT〈30．85s。结论年龄≥45岁和APTT指标降低是乳腺癌术后CMVT的独立危险因素。合并有高血压及冠心病的患者术CMVT的危险性较无高血压和冠心病的患者高。
Objective To explore the incidence of calf muscle vein thrombosis （ CMVT ） and underlying risk factors associated with CMVT in breast cancer patients after mastectomy. Methods Retrospectively reviewed 999 patients underwent mastectomy between 1 January 2012 and 30 November 2013 at the department of Breast Surgery, Qilu hospital of Shandong University. Patients were divided into two groups： control group and postoperational CMVT group. A detailed study on general clinical characteristics, laboratory test results, therapeutic regimen of breast cancer and clinical stage of breast cancer were acquired. Results Age^45, hypertension, coronary heart disease, and APTT〈30.85s were risk factors for breast cancer associated postoperative CMVT. They were included in the multivariable logistic regression analysis to derive adjusted risk of VTE in this population of mastectomy patients. After adjusting for other risk factors, we found that the independent risk factors for breast cancer postoperative CMVT were age≥45 and APTT〈30.85 s. Conclusions Elder age and low APTT are the independent risk factors for postoperative CMVT in breast cancer. Patients with hypertension and/or CHD have higher risk for postoperative CMVT than others.
出处
《浙江临床医学》
2017年第5期829-831,共3页
Zhejiang Clinical Medical Journal
