摘要
目的探讨2型糖尿病肾病患者早期甲状腺激素、自身抗体水平变化，为临床诊断提供依据。方法选择2型糖尿病患者80例，根据尿微量白蛋白排泄率（UAER）分为早期糖尿病肾病组（DKD组，30mg／24h〈UAER〈300mg／24h）与糖尿病非肾病组（NDKD组，UAER〈30mg／24h），以健康体检者为对照。检测糖化血红蛋白、肌酐、尿素氮、尿酸、尿微量白蛋白、T3、T4、FT3、FT4、TSH、TPOAb、TgAb、Tg。分析上述生化指标及甲状腺功能指标的差异。结果DKD组T3、FT3显著低于NDKD组，TSH水平高于NDKD组，差异有显著统计学意义（P〈0．01）。DKD组TPOAb、TgAb水平高于NDKD组，差异有统计学意义（P〈0．05）。结论T3、FT3、TGAb及TPOAb可以作为预测甲状腺疾病发生的指标。监测甲状腺激素变化和抗体水平，利于糖尿病肾病患者早期甲状腺功能异常的诊断。
Objective To explore the clinical applicability of thyroid autoantibody on type 2 diabetic kidney disease patients, and to provide evidence for clinical diagnosis. Methods This selected cases with type 2 diabetes from Zhejiang Provincial Hospital of TCM, the patients were divided into two groups according to urinary albumin excretion rate （ UAER ） , the early diabetic kidney disease group （ DKD group, 30mg/24h〈UAER〈300mg/24h ） , and diabetic with no kidney disease group （ NDKD group, UAER〈30mg/24h ） , healthy people were chosen as the c0ntrolgroup （Ngroup）.VariousbiochemicalindexesincludingHbAlc, Cr, BUN, UA, MA, T3, T4, FT3, FT4, TSH, TPOAb, TgAb, Tg were detected. The differences between the above biochemical indexes and thyroid function indexes were analyzed and discussed. Results The （ FT3, T3 ） levels of DKD group were significantly lower than the NDKD group, the level of TSH was just the opposite, the difference was statistically significant （ P〈0.01 ） . The levels of TPOAb and TgAb in group DKD were higher than that in NDKD group, and the difference was statistically significant （ P〈0.05 ） . Conclusion FT3, TGAb and TPOAb can be used as indicators to predict the occurrence of thyroid diseases. Monitoring the change of thyroid hormone and antibody level will have important significance in diabetic kidney disease＇s early diagnosis of early thyroid dysfunction.
出处
《浙江临床医学》
2017年第5期916-918,共3页
Zhejiang Clinical Medical Journal
