摘要
目的:探讨丙戊酸钠缓释片对癫痫患者氧化应激系统、认知功能及甲状腺激素水平的影响。方法:选取癫痫患者68例,随机分为治疗组与对照组各34例;治疗组采用丙戊酸钠缓释片治疗,对照组采用卡马西平治疗,两组均连续治疗6个月;检测并比较治疗前后两组氧化应激指标及甲状腺激素水平变化;采用MMSE量表评价两组患者认知功能。结果:治疗后两组MPO、SOD、CAT和GSH-Px水平较治疗前均明显下降,MDA水平显著上升,(P<0.05);治疗组治疗后上述指标改善明显优于对照组(P<0.05);对照组治疗后FT3、FT4水平较治疗前显著降低(P<0.05),且显著低于治疗组(P<0.05);两组治疗3、6个月后MMSE评分与治疗前比较均显著上升(P<0.05),治疗组治疗后各时间点MMSE评分显著高于对照组(P<0.05)。结论:丙戊酸钠对癫痫患者机体氧化/抗氧化平衡影响较小,可显著改善患者认知功能。
Objective： To explore the effect of sodium valproate retard tablet on the oxidative stress system, cognitive function, and thyroid hormone level in patients with epilepsy. Methods： A total of 68 patients with epilepsy were included in the study and randomized into the treatment group and the control group with 34 cases in each group. The patients in the treatment group were given sodium valproate retard tablets, while the patients in the control group were given earbamazepine. The patients in the two groups were treated continuously for 6 months. The oxidative stress indicators and thyroid hormone level hefore and after treatment in the two groups were detected and compared. MMSE was used to evaluate the cognitive function in the two groups. Results： MPO, SOD, CAT, and GSH-Px levels after treatment in the two groups were significantly reduced when compared with before treatment （P〈0.05）, while MDA level was significantly elevated （P〈0.05）. The improvement of the above indicators after treatment in the treatment group was significantly superior to that in the control group （P〈0.05）. FT3 and FT4 levels after treatment in the control group were significantly reduced when compared with before treatment （P〈0.05）, hut were significantly lower than those in the treatment group （P〈0.05）. MMSE score 3 and 6 months after treatment in the two groups was significantly elevated when compared with before treatment （P〈0.05）. MMSE score at each timing point after treatment in the treatment group was significantly higher than that in the control group （P 〈0.05）. Conclusions： The sodium valproate has a small effect on the balance of oxidation and anti-oxidation in patients with epilepsy, and can significantly improve the cognitive function.
出处
《海南医学院学报》
CAS
2017年第6期841-843,共3页
Journal of Hainan Medical University
基金
广州中医药大学学院教育教学课题(2015-1501)~~
关键词
癫痫
丙戊酸钠缓释片
氧化应激
认知功能
甲状腺激素
Epilepsy
Sodium valproate retard tablet
Oxidative stress
Cognitive function
Thyroid hormone
