摘要
目的探讨影响原发性小肠间质瘤(small intestinal stromal tumor,SIST)患者术后生存的因素。方法收集2007年12月-2015年12月空军总医院确诊SIST并行手术治疗的47例患者病例资料,回顾性分析各临床及病理因素对患者无病生存率的影响。结果 47例均完成随访,随访中位时间为33.5(2~102)个月。9例(19.15%)复发,7例(14.90%)死亡,术后复发及死亡平均间隔时间分别为18个月、33.8个月。术后1年、3年、5年无病生存率分别为86.1%、82.4%、73.2%,1年、3年、5年总生存率为91.0%、85.3%、76.3%。单因素分析筛选出肿瘤破裂、核分裂象、NIH危险度分级、肿瘤部位(P<0.05)为SIST术后复发转移危险因素。结论肿瘤破裂、肿瘤核分裂象、NIH危险度分级和肿瘤部位可能与小肠间质瘤预后有关。
Objective To analyze the factors impacting postoperative prognosis of the primary small intestinal stromal tumor （SIST）. Methods Clinical data about patients with resectable SIST admitted to the General Hospital of the Air Force from December 2007 to December 2015 were collected retrospectively, and univariate analysis were utilized to identify the clinicopathological indicators of disease free survival in resectable SIST. Results Total of 47 patients were followed up for a median of 33.5（2-102） months, 9（19.15%） patients suffered metastasis, 3（6.39%） recurred, and 7（14.90%） died. The mean interval between the surgery and recurrence or death was 18 months or 33.8 months, respectively. The 1, 3, 5-year disease-free survival rates after surgery were 86.1%, 82.4%, 73.2%, respectively, while the 1, 3, 5-year overall survival rates were 91.0%, 85.3%, 76.3%, respectively. The tumor rupture, tumor mitotic and tumor location were prognostic factors for tumor recurrence in SIST （P 〈 0.05）. Conclusion Tumor rupture, tumor mitotic and tumor location are probably related with tumor metastasis and recurrence in SIST.
出处
《解放军医学院学报》
CAS
2017年第3期206-208,212,共4页
Academic Journal of Chinese PLA Medical School
基金
首都特色基金(Z151100004015215)~~
关键词
小肠间质瘤
原发性
死亡率
复发转移
危险因素
small intestinal stromal tumor, primary
mortality
recurrence and metastasis
risk factors
