摘要
目的:探讨急性心肌梗死(AMI)合并糖尿病(DM)患者血清脂蛋白a[Lp(a)]、尿酸(UA)水平与心功能的相关性。方法:选择AMI合并DM患者70例(AMI+DM组),单纯AMI患者60例和单纯DM患者60例,健康人群60例(健康对照组)。AMI合并DM者又根据NYHA心功能水平分为I-II级组(58例)和III^IV级组(12例),根据预后情况分为无心血管事件组(54例)和心血管事件组(16例),检测各组血清Lp(a)、UA水平,并分析其相关性。结果:AMI+DM组血清Lp(a)、UA水平明显高于健康对照组、单纯AMI组和单纯DM组,且单纯AMI组、单纯DM组明显高于健康对照组(P均<0.01);与I^II级组比较,III^IV级组血清Lp(a)[(183.28±19.96)mg/L比(335.65±22.71)mg/L]、UA[(287.45±21.82)μmol/L比(437.79±26.72)μmol/L]水平明显升高(P均<0.01),与无心血管事件组比较,心血管事件组患者血清Lp(a)[(220.75±25.72)mg/L比(423.97±30.81)mg/L]、UA[(308.49±21.82)μmol/L比(442.97±29.75)μmol/L]水平明显升高(P均<0.01);Pearson相关分析显示,AMI合并DM患者血清Lp(a)、UA水平与心功能分级均呈明显正相关(r=0.410、0.412,P均<0.05),血清Lp(a)与UA之间呈明显正相关(r=0.496,P=0.023)。结论:急性心梗合并糖尿病患者血清脂蛋白、尿酸水平与其心功能密切相关,可以作为诊断及监测病情进展的指标。
Objective： To study correlation among serum levels of lipoprotein a [Lp （a）], uric acid （UA） and cardiac function in patients with acute myocardial infarction （AMI） complicated diabetes mellitus （DM）. Methods： A total of 70 AMI ＋ DM patients were enrolled as AMI ＋ DM group, 60 pure AMI patients were enrolled as pure AMI group, 60 pure DM patients were enrolled as pure DM group, and 60 healthy people were selected as healthy control group. According to NYHA cardiac function class, AMI ＋ DM patients were divided into class Ⅰ-Ⅱ group （n = 58） and class Ⅲ-Ⅳ group （n = 12） ; according to their prognosis, they were divided into no cardiovascular event group （n=54） and cardiovascular event group （n = 16）. Serum Lp （a） and UA levels were measured in all group, and their correlation were analyzed. Results： Serum Lp （a） and UA levels of AMI ＋ DM group were significantly higher than those of healthy control group, pure AMI group and pure DM group, and those of pure AMI group and pure DM group were significantly higher than those of healthy control group, P〈0.01 all; Pearson compared with class Ⅰ-Ⅱgroup, there were significant rise in serum levels of Lp （a） [ （183.28 ± 19.96） mg/L vs. （335.65 ± 22.71） mg/L], UA [ （287.45 ± 21.82） μmol/L vs. （437.79 ± 26.72） μmol/L] in class Ⅲ-Ⅳ group （P〈0.01 both） ; compared with no cardiovascular event group, there were significant rise in serum levels of Lp （a） [ （220.75 ± 25.72） mg/L vs. （423.97±30.81） mg/L] and UA [ （308.49±21.82） μmol/L vs. （442.97±29.75） μmol/L] in cardiovascular event group, P〈0.01 both; Pearson correlation analysis indicated that serum Lp （a）, UA levels were significant positively correlated with cardiac function class （r = 0. 410, 0. 412, P〈0.05 both）, and serum Lp （a） level was significant positively correlated with UA level （r = 0. 496, P = 0. 023） in AMI ＋ DM patients. Conclusion： Serum Lp （a）, UA levels are closely correlated with cardiac function in AMI ＋ DM patients, which can be used as indexes diagnosing and monitoring disease progress.
出处
《心血管康复医学杂志》
CAS
2017年第2期170-173,共4页
Chinese Journal of Cardiovascular Rehabilitation Medicine
关键词
心肌梗死
糖尿病
脂蛋白(A)
尿酸
Myocardial infarction
Diabetes mellitus
Lipoprotein （a）
Uric acid
