摘要
目的研究补阳还五汤化学成分。方法利用现代植物化学手段,对补阳还五汤的水提物进行硅胶柱层析,最后通过制备型液相色谱的方法得到纯的化合物单体,并通过现代波谱学的方法对其结构进行鉴定。结果从中共分离并鉴定了5个化合物,分别为xanthokeismins A(1),xanthokeismins B(2),2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone(3),5,7,3',4'-tetrahydroxy-2'-(3,3-dimethylallyl)isoflavone(4)和3-O-α-L-rhamnopyranosyl-(1-2)-β-D-glucuronopyranosyl-22-O-β,β-dimethylacryloyl-A1-barrigenol(5)。结论化合物1~5均为首次从补阳还五汤中分离得到。
Objective To investigate the anti-Alzheimer＇s disease active ingredients of BuyangHuanwu Decotion. Methods After the decotion was extracted and subjected to silica gel chromatography to obtain subfractions, then the purified compounds were isolated by pre-HPLC method. And their structures were elucidated by comprehensive spec- troscopic methods. Results Five compounds were separated and identified as xanthokeismins A （1）, xanthokeismins B （2）, 2＇,4＇-dihydroxy-6＇-methoxy-3＇,5＇-dimethylchalcone （3）,5,7,3＇,4＇-tetrahydroxy-2＇-（3,3-dimethylallyl） isoflavone （4）, and 3-O-α-L-rhamnoyranosyl-（1-2）-β-D-glucuronoyranosyl-22-O-β,β-dimethylacryloyl-A 1 -barrigenol （5）,respectively. Conclusion Compounds 1-5 were isolated from BuyangHuanwu Decotion for the first time.
出处
《中国医药导报》
CAS
2017年第11期15-17,共3页
China Medical Herald
基金
国家自然科学基金资助项目(81373777)
关键词
补阳还五汤
化学成分
分离
结构鉴定
阿尔茨海默病
BuyangHuanwu Decoction
Chemical Constituents
Isolation
Identification
Alzheimer＇s Disease
