摘要
目的探讨乌司他丁联合大剂量氨溴索治疗重症肺炎的效果。方法选取我院2013~2016年期间收治的确诊为重症肺炎患者的相关临床数据,从中随机抽取80例,以患者所接受干预方案差异为标准将其分为对照组、观察组,每组40例,采取常规重症肺炎对症治疗者为对照组,联合乌司他丁和大剂量氨溴索治疗者为观察组。比较两组患者的临床效果、治疗前后血气指标水平以及6 min步行距离情况。结果观察组总有效率(95.0%)高于对照组(82.5%);治疗后患者血氧分压和氧合指数水平均有所提高,且观察组水平[(61.2±10.3),(296.3±23.1)mmHg]高于对照组[(56.2±10.3),(159.1±25.7)mmHg];治疗后两组患者6 min步行距离均延长,且观察组[(289.1±20.2)m]患者步行距离长于对照组[(256.9±19.8)m],以上差异均有统计学意义(P<0.05)。结论重症肺炎患者具有病情严重、预后质量较差等特点,为此类患者制定干预方案时除了考虑改善病情,还应该对各项指标以及康复质量等有所关注,乌司他丁联合大剂量氨溴索对该病不但能够控制病情,且血气指标水平和6 min步行距离也得到相对更为明显的提升,具有全面性优点,值得推广。
Objective To explore efficiency of ulinastatin combined high-dose ambroxol on patients with severe pneumonia.Methods Clinical datas of patients in our hospital diagnosed with severe pneumonia from 2013-2016 were selected, from which a random sample of 80 cases were selected and divided into the control group and the observation group according to the intervention methods,with 40 cases in each group.Patients in the control group were received the general treatment for severe pneumonia,while patients in the observation group were received ulinastatin combined high-dose ambroxol on the basis of the control group.The ehilical effect,the level of blood gas index and the walking distance of patients between two groups were compared.Results The effective rate of patients in the observation group （95.0%） was higher than that in the control group （82.5%）.After treatment,the levels of blood oxygen pressure and oxygenation index of patients in the observation group [（61.2±10.3）,（296.3±23.1）mmHg] were higher than those in the control group[（56.2±10.3）, （159.1±25.7）mmHg]; 6 minutes walking distance in of patients in the observation group [（2.89.1±20.21）m] were longer than that in the control group[（256.9±19,8）m].All the differences were statistically significant （P〈0.05）.Conclusion The prognosis of severe pneumonia patients with severe pneumonia poor quality,intervention plans for such patients in addition to consider to improve the condition, also should be to focus on the indicators and the quality of rehabilitation, ulinastatin combined high-dose ammonia bromine, the disease can not only control the condition and blood gas index and 6 minutes walking distance is relatively more obvious increase, also has comprehensive advantages, is worth promoting.
出处
《中国当代医药》
2017年第10期128-130,共3页
China Modern Medicine
关键词
乌司他丁
氨溴索
重症肺炎
Ulinastatin
Ambroxol
Severe pneumonia
