摘要
胚胎在具有容受性的内膜中充分植入是成功妊娠的前提,胚胎植入是一个受到精确调控的生理过程,可概括为胚胎的定位、黏附和侵入3个阶段。血管新生贯穿于子宫内膜周期性变化和胚胎植入过程,并为胚胎的发育提供了重要的物质基础。本文就血管内皮生长因子(VEGF)、成纤维细胞生长因子(FGF)、转化生长因子(TGF)、血管生成素(Ang)、整合素(integrin)等血管新生相关因子,在胚胎植入前内膜准备和胚胎植入过程中的表达规律及子宫内膜血流灌注超声评价2个方面进行综述,为进一步干预血管新生过程,改善子宫内膜容受性和提高胚胎种植成功率奠定基础。
Successful pregnancy is dependent upon the adequate implantation of a competent embryo into receptive endometrium. Embryo implantation is regulated by a complicated physiological process, involving apposition, adhesion and invasion. Vasculogenesis occur in menstrual cycle and implantation process supplying important substance for the development of embryo. This paper will review the expression regularity of angiogenesis related factors, such as vascular endothelial growth factor （VEGF）, fibroblast growth factor （FGF）, transforming growth factor （TGF）, angiogenin （Ang） and integrin, in the process of membrane preparation and embryo implantation, and uterine blood flow perfusion ultrasound evaluation, which further lay the foundation for improving endometrial receptivity and increasing embryo implantation rate.
作者
王嘉宁
周莹
夏飞
Wang Jianing Zhou Ying Xia Fei(Department of Reproductive Center, the First Affiliated Hospital of Soochow University, Suzhou 215000, China)
出处
《中华生殖与避孕杂志》
CAS
CSCD
北大核心
2017年第3期240-244,共5页
Chinese Journal of Reproduction and Contraception
基金
江苏省卫生厅项目(H201311)
苏州市卫生局科技项目(LCXZ201302)
苏州市医学重点学科(生殖医学)资助~~
关键词
胚胎植入
血管新生
内膜容受性
超声
Embryo implantation
Angiogenesis
Endometrial receptivity
Ultrasound
