摘要
目的:探究川崎病(KD)患儿血浆吲哚胺2,3双加氧酶(IDO)含量变化与其发病的相关性。方法:选取2015年1月—2015年3月心血管内科住院的KD患儿20例作为观察组,另选择20例健康体检儿童作为对照组,采用酶联免疫吸附试验(ELISA)分别检测观察组急性期及恢复期血浆IDO含量以及对照组血浆IDO含量,并进行比较。结果:观察组KD患儿急性期IDO含量明显增高,与对照组及恢复期IDO含量比较,差异有统计学意义(P<0.01)。观察组恢复期IDO含量与对照组比较差异无统计学意义(P>0.05)。各组内男女不同性别之间血浆IDO含量比较差异无统计学意义(P>0.05)。结论:血浆IDO在川崎病患儿急性期含量增高,可能参与了KD患儿急性期免疫性炎症反应。IDO的表达水平与性别无关。
Objective： To detect the level of IDO in patients with Kawasaki disease and analyze correlation between IDO and Kawasaki disease. Methods： Selected 20 cases of KD hospitalized in January 2015 to March 2015 and 20 cases of healthy volunteers. Enzyme-linked immunosorbent assay（ ELISA） was adopted to detect the serum levels of IDO. The detection results of all those cases were compared and analyzed. Results： The serum IDO level of the acute phase KD group was significantly higher than that of both the normal control group and the recovery phase KD group（ P 0. 01）. There is no significant difference of IDO level between the recovery phase KD group and the normal control group（ P 0. 05）. There is also no significant gender difference of IDO level among all those groups（ P 0. 05）. Conclusion： The serum IDO level increased in the acute phase KD patients. It might was involved in the acute immune reaction of KD. The IDO level might was not affected by gender.
出处
《临床医药实践》
2017年第4期253-255,共3页
Proceeding of Clinical Medicine
基金
浙江省中医药普通项目研究资助项目(项目编号:2009CB048)
浙江省教育厅科研项目(项目编号:Y201017610)
关键词
川崎病
吲哚胺2
3双加氧酶
酶联免疫吸附试验
kawasaki disease
indoleamine 2
3 dioxygenase
enzyme linked immunosorbent assay
