摘要
目的 探讨金华市人民医院门诊女性宫颈上皮细胞人乳头瘤病毒（HPV）的感染情况及亚型分布情况.方法 采用基因芯片法对就诊的妇女进行26种HPV亚型检测,对各亚型的感染情况进行分析.结果 984例就诊患者中共检出25种HPV亚型,检出率排在前三为16型、58型、52型.HPV总阳性率为36.89％.其中高危型检出率为25.91％,低危型检出率为5.69％,多重感染率为5.28％.21～30岁、〉30～40岁、〉40岁3个年龄组中HPV检出率分别为42.33％,35.23％,35.94％.其中3个年龄组在HPV高危型检出率、低危型检出率及多重感染率差异有统计学意义（χ^2 =71.58,P〈0.05）.结论 HPV16、58、52型是金华市人民医院就诊患者女性感染的主要高危基因型;HPV基因分型对宫颈癌的早期预防、治疗、病因学及HPV疫苗的研究具有重要意义.
Objective To detect the infection and subtype distribution of human papillomavirus （HPV） in cervical epithelial cell line in the People＆#39;s Hospital of Jinhua.Methods 26 kinds of HPV genotypes were detected by gene chip,and the infection states among all subtypes were analyzed.Results A total of 25 genotypes of HPV were identified in 984 female patients,with the positive rate of 36.89%.The top three common high-risk HPV,ranging from high to low according to positive rate were HPV-16,58 and 52.The positive rates of high-risk HPV,low-risk HPV and multiple infection rate were 25.91%,5.69% and 5.28%,respectively.The positive rates of the age groups of 21-30 years,〉 30-40 years and 〉 40 years were 42.33 %,35.23% and 35.94%,respectively.There were significant differences among the three age groups in the detection rate of high-risk HPV,low-risk type and multiple infection rate（χ^2 =71.58,P 〈 0.05）.Conclusion HPV 16,58 and 52 are the main high-risk genotypes of the 984 women in our hospital.The genotyping of HPV has important significance in the prevention,treatment and etiology of cervical cancer,as well as in the study of HPV vaccine.
出处
《中国基层医药》
CAS
2017年第8期1225-1228,共4页
Chinese Journal of Primary Medicine and Pharmacy
