hTERC、C-MYC基因检测在新疆维吾尔族妇女宫颈病变筛查中的意义被引量：4

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摘要目的探讨人端粒酶RNA(hTERC)及原癌基因C-MYC在新疆维吾尔族妇女宫颈病变筛查中的临床应用价值。方法收集1 000例新疆维吾尔族妇女的宫颈脱落细胞,均行宫颈液基薄层细胞学(TCT)、高危型HPV筛查(HR-HPV)及荧光原位杂交技术(FISH)检测hTERC和C-MYC基因,任一指标阳性者行阴道镜下活检,分析hTERC、C-MYC基因在细胞学及病理学分级中的表达水平,ROC曲线分析hTERC和C-MYC基因单一和联合检测对高级别宫颈病变(≥CINⅡ期)的临床诊断效能。结果hTERC、C-MYC基因表达水平均随宫颈病变程度的升高而升高。hTERC基因单独诊断宫颈高级别病变(≥CINⅡ期)的ROC曲线下面积(AUCROC)为0.879,C-MYC基因为0.835,两者联合检测为0.904,且两者联合检测的敏感性(90.77%)、阴性预测值(96.00%)和准确性(90.22%)均高于单一指标检测。结论 hTERC、C-MYC基因可作为临床宫颈病变高级别筛查的指标。

作者范玲玲黄修菊刘新莲王丹祖力比艳.依玛木江陈志芳

机构地区新疆医科大学第一附属医院妇产科

出处《临床检验杂志》 CAS CSCD 2017年第3期196-198,共3页 Chinese Journal of Clinical Laboratory Science

关键词宫颈癌细胞学检查高危人乳头瘤病毒人端粒酶RNA基因 C-MYC基因

分类号 R737.33 [医药卫生—肿瘤]

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