摘要
目的:通过调研某三甲医院内分泌科住院的糖尿病患者使用糖尿病周围神经病变(diabetic peripheral neuropathy,DPN)治疗药物的情况,分析其用药合理性,为临床合理用药提供参考。方法:调研2015年5月1日—2016年3月31日期间住院的糖尿病患者使用DPN治疗药物的情况,根据相关指南、药品说明书及文献,评价其用药的适宜性,包括适应证、用法用量、溶媒配伍及相互作用等方面;根据多伦多临床评分系统(Toronto Clinical Scoring System,TCSS),评估患者入院及出院时是否存在周围神经病变及其严重程度,评价DPN治疗药物的短期疗效;通过观察患者院内不良反应的发生情况,评价短期用药的安全性。结果:本研究共纳入302例患者,其中存在DPN的患者所占比例是76.16%。在这些患者中,使用DPN治疗药物的比例是66.09%。DPN治疗药物无适应证用药及用法用量存在问题的比例为16.36%。使用较多的2组治疗方案"硫辛酸注射液+注射用腺苷钴胺"、"注射用腺苷钴胺"对DPN有效,2组患者TCSS出院评分小于入院评分,差异具有统计学意义。院内使用DPN治疗药物的患者仅发生2例不良反应。结论:DPN治疗药物在内分泌科使用广泛且较为合理,使用的适宜性有待提高,有一定疗效,按说明书推荐方法使用安全性较好。
Objective： To evaluate the rationality of use of medications for diabetic peripheral neuropathy（ DPN） in diabetic patients hospitalized in the department of endocrinology in one hospital and provide reference for clinical rational use of drugs. Methods： The use of medications for DPN in diabetic inpatients from May 1st 2015 to March 31 th 2016 were investigated. The appropriateness of indication,dosage,administration,solvent and drug interactions were evaluated according to the labelings,guidelines and literatures. The efficacy was evaluated on admission and at discharge according to the Toronto Clinical Scoring System（ TCSS）. And the safety was evaluated through observing the incidences of adverse drug reactions. Results： Three hundred and two patients were included for the analysis. 76. 16% patients were diagnosed with DPN. 66. 09% of these patients used medications for DPN.16. 36% of the medications for DPN were not appropriate. Thioctic Acid Injection ＆ Cobamamide for Injection and Cobamamide for Injection were used the most frequently and were both effective. The TCSS scores of the patientsusing the two medications at discharge were both lower than the scores on admission and the differences were statistically significant. There were only two cases of adverse drug reactions observed in the study. Conclusion：Medications for DPN are widely used in the department of endocrinology and they are used rationally in most cases with certain efficacy,however,there is still room for improvement of medication appropriateness. It is generally safe when using according to the labelings.
出处
《中国新药杂志》
CAS
CSCD
北大核心
2017年第8期960-964,共5页
Chinese Journal of New Drugs
