摘要
目的:探讨干扰素治疗带状疱疹的疗效以及对患者细胞免疫功能的影响。方法:选择我院2013年12月至2014年12月收治的带状疱疹患者90例,随机分为观察组和对照组,各45例。对照组患者给予伐昔洛韦治疗。观察组患者在对照组治疗的基础上加以干扰素治疗。观察两组患者治疗前后4周外周血CD3、CD4以及CD8水平情况;比较止痛时间、止疱时间、结痂时间以及脱痂时间;接受治疗三个月后记录后遗神经痛(PHN)的发生率。结果:观察组患者总有效率为97.78%高于对照组患者77.78%,差异具有统计学意义(P<0.01)。观察组患者止痛时间(2.24±0.56)d、止疱时间(1.56±0.69)d、结痂时间(4.58±1.04)d以及脱痂时间(7.26±1.48)d均短于对照组患者止痛时间(5.69±0.58)d、止疱时间(3.02±0.82)d、结痂时间(6.89±1.07)d以及脱痂时间(13.65±1.57)d,差异具有统计学意义(P<0.01)。治疗后,观察组患者CD3水平(66.38±7.62)×10^(-2)、CD4水平(39.71±7.55)×10^(-2)、CD8水平(29.67±7.23)×10^(-2)以及CD4/CD8水平(1.49±0.16)×10^(-2)均高于对照组CD3水平(58.97±8.36)×10^(-2)、CD4水平(32.30±7.69)×10^(-2)、CD8水平(25.34±7.22)×10^(-2)以及CD4/CD8水平(1.19±0.14)×10^(-2),差异具有统计学意义(P<0.01)。观察组患者后遗神经痛的发生率为6.67%低于观察组患者后遗神经痛的发生率的31.11%,差异具有统计学意义(P<0.01)。结论:干扰素治疗带状疱疹能够有效改善患者免疫功能,预防患者出现带状疱疹后神经痛。
Objective：To study the effects of interferon treatment of herpes zoster and its impact on cellular immune function in patients. Methods：90 patients with herpes zoster treated in our hospital from December 2013 to December 2014 were randomly divided into observation group and control group, 45 cases in each. The control group was treated with valacyclovir therapy. The observation group was treated with interferon and valacyclovir therapy. The level of CD3,CD4 and CD8 were compared after 4 weeks, and pain relief time, blistering time, scab off time and crusting time were compared. The PNH rate of the two groups was compared after three monthes. Results： The total effective rate was 97.78% in the observation group patients, which were higher than 77.78% in the control group of patients, the difference was statistically significant （P〈0.01）. Pain relief time（2.24±0.56）d, blistering time（1.56±0.69） d, crusting time （4.58±1.04） d and the scab off time（7.26±1.48）d in the observation group of patients were shorter than pain relief time （5.69±0.58） d, blistering time （3.02±0.82）only d, crusting time （6.89±1.07） d and the scab off time （13.65±1.57）d in the control group of patients, a statistically significant difference（P〈0.01）. After treatment, CD3 levels（66.38±7.62）x10-2, CD4 levels（39.71±7.55）x10-2,CD8 levels （29.67±7.23）x10-2and CD4/CD8 levels（1.49±0.16 ）x10-2 CD3 levels in the observation group of patients were higher than CD3 levels（58.97±8.36）x10-2, CD4 levels （32.30±7.69）x10-2,CD8 levels（25.34±7.22）x10-2 and CD4/CD8 levels （1.19±0.14）x10-2 in the control group of patients, the difference was statistically significant （P〈0.01）. Occur in patients with postherpetic neuralgia in the observation group was 6.67% lower than the 31.11% of patients in the observation group, the difference was statistically significant（P〈0.01）. Conclusion：Interferon treatment of herpes zoster can improve immune function in patients, and prevention of post-herpetic neuralgia patients.
出处
《河北医学》
CAS
2017年第4期600-603,共4页
Hebei Medicine
基金
北京市科技计划项目
(编号:201402695)
