摘要
目的观察茜根散联合糖皮质激素对过敏性紫癜患儿可溶性细胞间黏附分子-1(s ICAM-1)、可溶性血管细胞黏附分子-1(s VCAM-1)表达水平的影响。方法将122例过敏性紫癜患儿随机分为2组,对照组61例在常规治疗的基础上给予氢化可的松治疗,研究组61例在对照组治疗基础上加用茜根散治疗,均以3个月为1个疗程。观察2组治疗前后s ICAM-1、s VCAM-1、可溶性CD146(s CD146)、白细胞三烯B4(LTB4)、白细胞介素-6(IL-6)、IL-8、肿瘤坏死因子-α(TNF-α)水平,记录2组临床症状消失时间和不良反应,统计2组临床疗效。结果研究组治疗后s ICAM-1、s VCAM-1、s CD146、LTB4、IL-6、IL-8和TNF-α水平均较对照组显著降低(P均<0.05),紫癜、关节痛、腹痛及蛋白尿消失时间均显著短于对照组(P均<0.05),临床疗效显著优于对照组(P<0.05)。结论茜根散联合糖皮质激素治疗过敏性紫癜可提高临床效果,值得临床推广应用。
Objective It is to observe expression of Qiangen powder combined with glucocorticoids on soluble intercellular adhesion molecules - 1 （sICAM） and soluble vascular cell adhesion molecule-1 （ sVCAM-1 ） in children with anaphylactoid purpura. Methods 122 cases of children with allergic purpura were randomly divided into 2 groups, control group （n = 61 ） was given hydrocortisone on the basis of normal treatment, while the treatment group （n = 61 ） was given Qiangen powder on the basis of treatment in control group, 3 months as one treatment course. The levels of sICAM-1, sVCAM-1, soluble CD146 （sCD146） , leukotrienes B4（ LTB4）, IL-6, IL-8, TNF-α were observed before and after treatment in both groups. The disap- pearing time of clinical symptom and occurrence of side effect were recorded, and the clinical curative effect was evaluated. Results After treatment, the levels of sVACM, sICAM-1, sCD146, LTB4, IL-6, IL-8 and TNF-α in study group were signifi- cantly lower than that in control group （ P 〈 0.05 ）. The disappearing time of purpura, joint pain, abdominal pain, proteinuria were significantly shorter in study group than that in control group （P 〈 0.05）. The clinical curative effect was better of study group than that of control group （ P 〈 0.05 ）. Conclusion Qiangen powder combined with glucocorticoids can improve the clin- ical effect in the treatment of allergic purpura, which is worthy of clinical popularization and application.
出处
《现代中西医结合杂志》
CAS
2017年第14期1502-1504,1527,共4页
Modern Journal of Integrated Traditional Chinese and Western Medicine
