摘要
目的 了解Turner综合征（TS）患儿自身免疫性甲状腺抗体（TAA）的变化特点及其与甲状腺功能、年龄、核型、血脂代谢异常的关系。方法 收集2007年7月至2015年7月中山大学孙逸仙纪念医院32例经染色体核型分析确诊的TS患儿临床资料，检测血清TAA，将患儿分为TAA阳性组与TAA阴性组，对2组患儿的甲状腺功能、年龄、染色体核型和血脂情况进行对比分析。结果 TAA阳性患儿23例（23/32例，71.88%），其中甲状腺功能异常9例（9/23例，39.13%）；TAA阴性患儿9例（9/32例，28.12%），其中甲状腺功能异常3例（3/9例，33.33%）。TAA阳性组与TAA阴性组年龄分别为（12.08±2.90）岁和（8.89±4.17）岁，2组间比较差异有统计学意义（t＝101.500，P＝0.047）。按年龄分为0～5岁、〉5～10岁、〉10～15岁和〉15岁4组，各年龄组TAA阳性率分别为25.00%（1/4例）、75.00%（6/8例）、82.35%（14/17例）和66.67%（2/3例）。32例TS患儿检测脂代谢20例，出现脂代谢紊乱者11例（11/20例，55.00%），其中TAA阳性患儿9例（81.82%），TAA阴性患儿2例（18.18%），2组脂代谢紊乱发病率比较差异有统计学意义（χ2＝4.848，P＝0.028）；TS各种核型之间与TAA阳性率差异无统计学意义（χ2＝4.246，P＝0.120）。结论 TS合并TAA阳性患儿易出现甲状腺功能异常及脂代谢紊乱，应定期监测TAA及甲状腺功能，必要时随诊脂代谢相关检查。
Objective To investigate the changes of thyroid autoantibody （TAA） in children with Turner syndrome（TS）, and its association between TAA and thyroid dysfunction, age, karyotype and dyslipidaemia.Methods Thirty-two patients with TS diagnosed by chromosome analysis hospitalized at Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University from July 2007 to July 2015 were divided into 2 groups based on TAA-positive or TAA-negative, then the thyroid dysfunction, the age, the karyotype and the lipid metabolism were compared between 2 groups.Results Of the 23 cases of TAA-positive girls（23/32 cases, 71.88%）, 9 girls（39.13%） suffered from thyroid dysfunction; of the 9 cases of TAA-negative girls （9/32 cases, 28.12%）, 3 girls（33.33%） had thyroid dysfunction.As compared with the girls in TAA-negative group, the age in TAA-positive group was significantly higher[（12.08±2.90） years old vs.（8.89±4.17）years old], and the difference was significant（t=101.500, P=0.047）. The patients were divided into 4 age groups： 0-5 years old, 〉5-10 years old, 〉10-15 years old and 〉15 years old; the rates with TAA-positive were 25.00% （1/4 cases）, 75.00%（6/8 cases）, 82.35% （14/17 cases） and 66.67%（2/3 cases） respectively.Twenty patients received the lipid metabolism test, and 11 cases（11/20 cases, 55.00%） of them suffered from dyslipidaemia, 9 cases of them were TAA-positive （9/11 cases, 81.82%）, and 2 cases were TAA-negative（2/11 cases, 18.18%）. The differences in the prevalence of dyslipidaemia between the 2 groups were significant （χ2=4.848, P=0.028）. There was no significant difference in the numbers of TAA-positive cases among different karyotypes（χ2 =4.246, P=0.120）.Conclusions Patients with TS are prone to suffer from thyroid dysfunction and dyslipidaemia.Timely detection of TAA and thyroid function is recommended, as well as the lipid metabolism if necessary.
出处
《中华实用儿科临床杂志》
CSCD
北大核心
2017年第8期579-581,共3页
Chinese Journal of Applied Clinical Pediatrics
