摘要
目的探讨肥胖型多囊卵巢综合征(PCOS)患者血清左旋肉毒碱水平的变化及意义。方法选取2014年5月~2016年9月内蒙古医科大学附属医院妇产科门诊确诊的PCOS患者60例,依据体重指数(BMI)分为非肥胖PCOS组(BMI<30 kg/m^2,n=32)及肥胖PCOS组(BMI≥30 kg/m^2,n=28)。选取同期就诊的28例月经周期规律的生育期妇女为对照组。采用酶联免疫吸附试验测定血清左旋肉毒碱水平,并分析其与肥胖、胰岛素抵抗及性激素的相关性。结果与非肥胖PCOS组比较,肥胖PCOS组的BMI、腰臀比及Ferriman-gallwey评分均升高,多毛症状人数增多,差异有统计学意义(P<0.05)。与对照组比较,非肥胖PCOS组、肥胖PCOS组的多毛症状、不规则月经及月经周期紊乱增多,Ferriman-gallwey评分升高,差异有统计学意义(P<0.05)。与非肥胖PCOS组比较,肥胖PCOS组的HOMA-IR及胰岛素抵抗例数升高,左旋肉毒碱水平降低,差异有统计学意义(P<0.05)。与对照组比较,非肥胖、肥胖PCOS组的左旋肉毒碱水平降低,肥胖PCOS组的HOMA-IR及胰岛素抵抗例数升高,差异有统计学意义(P<0.05)。肥胖PCOS患者血清左旋肉毒碱水平与BMI及HOMA-IR呈负相关(P<0.05),而与E_2、睾酮、FSH、DHEAS等指标无相关性(P>0.05)。结论血清左旋肉毒碱水平在肥胖型PCOS患者中降低,且与BMI及HOMA-IR呈负相关,提示其可能参与疾病进程。
Objective To discuss the changes and significance of plasma L-carnitine levels of patients with obese polycystic ovary syndrome （PCOS）. Methods 60 diagnosed patients with PCOS in Affiliated Hospital of Inner Mongolia Med- ical University from May 2014 to September 2016 were selected and divided into non obese PCOS group （BMI 〈30 kg/m2, n = 32）and obese PCOS group （BMI^30 kg/m2, n=28） according to BMI. 28 cases of menstrual cycle were selected as control group. The plasma L-carnitine levels were determined by enzyme-linked immunosorbent assays. And its corre- lation with obesity, insulin resistance and sex hormones were analyzed. Results Compared with non-obesity PCOS group, BMI, waist/hip ratio, Ferriman-gallwey score of obesity PCOS group were increased and the number of hirsutism was increased, the differences were statistically significant （P 〈 0.05）. Compared with control group, the febrile symp- toms, irregular menstruation and menstrual cycle disorder, Ferriman-gallwey scores in non-obese PCOS group, obese PCOS group were increased, the differences were statistically significant （P 〈 0.05）. Compared with non-obese PCOS group, HOMA-IR and insulin resistance in obese PCOS group were increased, and the level of L-carnitine was decreased, the differences were statistically significant （P 〈 0.05）. Compared with control group, the levels of L-carnitine in non-obese PCOS group and obese PCOS group were decreased, and the number of HOMA-IR and insulin resistance in obese PCOS group were higher, the differences were statistically significant （P 〈 0.05）. There was negative correlation between serum L-carnitine level and BMI, HOMA-IR in obese PCOS patients （P 〈 0.05）, the levels of serum L-carnitine in obese PCOS patients were not correlated with E2, testosterone, FSH and DHEAS （P 〉 0.05）. Conclusion Serum L-carnitine levels are reduced in obese PCOS patients and negatively correlated with BMI and HOMA-IR, suggesting that they may be involved in disease progression.
出处
《中国医药导报》
CAS
2017年第12期109-112,共4页
China Medical Herald
