摘要
目的探讨胃神经内分泌肿瘤(GNENs)的临床特征,以提高临床医师对本病的认识。方法收集2005年10月至2015年10月北京协和医院收治的36例GNENs,对其人口学特征、主要临床表现、内镜下表现、病理特征及治疗情况进行回顾性分析。结果 36例患者平均年龄(55.8±11.1)岁,男女比例0.89∶1。临床表现多种多样,腹痛的发生率高达42.9%。63.9%的病变分布于胃体部。内镜下病变可表现为息肉样隆起、溃疡性病变、黏膜凹陷。以息肉样隆起最为多见,其中73.9%为单发病变,平均直径小于10 mm。病理分级包括G1~G3级,以G1级居多(55.6%)。65.2%于胃体行活检的患者病理证实存在胃体黏膜萎缩或肠化。治疗方案主要包括内镜和手术根治。结论 GNENs缺乏特异性临床表现,病变以胃体分布居多,在内镜下多表现为息肉样隆起。对于合并萎缩性胃炎,尤其胃体萎缩的息肉样病变,应警惕GNENs的可能性。
Objective To explore the clinical features of gastric neuroendocrine neoplasms（ GNENs）.Methods A total of 36 patients with GNENs who were diagnosed between October 2005 and October 2015 at Peking Union Medical College Hospital were retrospectively analyzed. The demographic characteristics, clinical manifestations,endoscopic findings,and pathologic features as well as the treatments of GNENs were collected and analyzed. Results The average age of 36 patients was（ 55. 8 ± 11. 1） years and the male to female ratio was0. 89∶1. The clinical manifestations varied,in which abdominal pain was as high as 42. 9%. Also,63. 9% of the lesions were distributed in the gastric body. The endoscopic appearance of GNENs included polypoid lesions,ulcerative lesions,and mucosal depression. Polypoid lesions were most common,and 73. 9% of these polyps were single,with an average diameter of less than 10 mm. Pathological grading included G1-G3 level,while G1 level accounted for 55. 6%. Up to 65. 2% of patients who undergone gastric body biopsy had pathologic evidence of mucosa atrophy or metaplasia. Therapeutic modalities included endoscopic intervention and surgical resection.Conclusions Patients with GNENs lack specific symptoms. The most common endoscopic appearance is polypoid lesions,mainly in gastric body. Clinicians should be aware of the possibility of GNENs in the polypoid le-sions,particularly for those accompanied with gastric body atrophy.
出处
《中国医学科学院学报》
CAS
CSCD
北大核心
2017年第2期211-214,共4页
Acta Academiae Medicinae Sinicae
关键词
胃神经内分泌肿瘤
临床表现
内镜
病理
gastric neuroendocrine neoplasms
clinical manifestations
endoscopy
pathology
