摘要
目的探讨放疗与低剂量奈达铂化疗联合治疗老年食管癌的临床效果。方法选取124例老年中晚期食管癌患者为研究对象,按随机数字表法将患者分为三组:单纯放疗的患者为单放组40例,放疗联合低剂量(20 mg/m2)奈达铂治疗的患者为放化1组42例,放疗联合高剂量(30 mg/m2)奈达铂治疗的患者为放化2组42例。治疗2个月后比较三组临床近期疗效,并观察三组治疗期间毒副反应发生情况。结果三组近期疗效比较差异有统计学意义(P<0.05),其中放化1组疗效最佳,放化2组次之,单放组疗效最差。三组Ⅰ~Ⅱ度、Ⅲ~Ⅳ度恶心或呕吐、Ⅰ~Ⅱ度放射性肺炎、Ⅰ~Ⅱ度放射性食管炎发生率比较差异有统计学意义(P<0.05),其中放化2组发生率明显高于单放组和放化1组(P<0.05);放化2组Ⅲ~Ⅳ度食欲减退、Ⅲ~Ⅳ度放射性食管炎、Ⅲ~Ⅳ度骨髓抑制发生率明显高于单放组(P<0.05);而放化1组仅Ⅲ~Ⅳ度食欲减退、Ⅲ~Ⅳ度骨髓抑制发生率明显高于单放组(P<0.05);单放组和放化1组毒副反应以Ⅰ~Ⅱ为主,经对症治疗干预后均可明显缓解。结论与单纯放疗、放疗联合高剂量奈达铂化疗相比,放疗同步低剂量奈达铂化疗治疗老年食管癌近期疗效更显著,毒副反应轻微,更安全可靠。
Objective To explore the clinical effect of radiotherapy combined with low-dose nedaplatin chemotherapy in treatment of elderly patients with esophageal cancer.Methods 124 elderly patients with advanced esophageal cancer were selected as the study subjects and by the random number table method,they were divided into group A（n = 40,treated with radiotherapy alone）,group B [n = 42,treated with radiotherapy combined with lowdose（20 mg/m^2） nedaplatin chemotherapy]and group C[n = 42,treated with radiotherapy combined with high-dose（30 mg/m^2） nedaplatin chemotherapy].The short-term effects and the incidence of side effects were compared among the three groups two months after the treatment.Results The short-term curative effect of group B was the best,followed by group C,and the effect of group A was the worst（P〈0.05）.There were significant differences in the incidence rates of Ⅰ - Ⅱ level and Ⅲ - Ⅳ level of nausea or vomiting,Ⅰ - Ⅱ level of radiation-induced pneumonia and Ⅰ - Ⅱ level of radioaction esophagitis between the groups（P〈0.05）,and the incidence rates of group C were significantly higher than those of group B and group A（P〈0.05）; The incidence rates of Ⅲ - Ⅳ level of anorexia and Ⅲ - Ⅳ level of radioaction esophagitis and Ⅲ - Ⅳ level of myelosuppression in group C were significantly higher than those in group A（P〈0.05）,and the incidence rates of Ⅲ - Ⅳ level of anorexia and Ⅲ - Ⅳ level of myelosuppression in group B were significantly higher than those in group A（P〈0.05）.The side effects of group A and group B were Ⅰ - Ⅱ level,and after symptomatic treatment,the symptoms were significantly alleviated.Conclusion Compared with those of radiotherapy alone and radiotherapy combined with high-dose nedaplatin chemotherapy,the effect of radiotherapy combined with low-dose nedaplatin is safer and more significant in the treatment of elderly patients with esophageal cancer.
出处
《中国临床新医学》
2017年第4期321-324,共4页
CHINESE JOURNAL OF NEW CLINICAL MEDICINE
关键词
放疗
低剂量
奈达铂
化疗
老年食管癌
Radiotherapy
Low-dose
Nedaplatin
Chemotherapy
Elderly esophageal cancer
