摘要
目的:探讨培哚普利联合螺内酯对慢性心力衰竭患者神经内分泌的影响。方法:选取2015年9月—2016年8月河南省桐柏县人民医院收治的慢性心力衰竭患者88例作为研究对象,以随机数字表法分为观察组和对照组,每组44例。对照组患者给予抗心力衰竭标准化治疗,观察组患者给予培哚普利联合螺内酯治疗。比较两组患者治疗前后的神经内分泌变化。结果:治疗后,观察组患者N-末端B型利钠肽原、血管紧张素Ⅱ及醛固酮水平均明显低于对照组,左心室射血分数明显高于对照组,差异均有统计学意义(P<0.05)。结论:培哚普利联合螺内酯治疗慢性心力衰竭可有效抑制神经内分泌系统激活,减轻心肌细胞损伤和心室重构,有利于预后。
OBJECTIVE：To investigate effects of perindopril combined with spironolactone on neuroendocrine in patients with chronic heart failure. METHODS： 88 patients with chronic heart failure admitted into Henan Tongbai County People＇s Hospital from Sept. 2015 to Aug. 2016 were selected to be divided into observation group and control group via the random number table, with 44 cases in each. The control group were treated with standardized treatment of anti-heart failure, while the observation group were given perindopril combined with spironolactone. Changes of neuroendocrine of two groups were compared before and after treatment. RESULTS： After treatment, levels of NT- proBNP, Ang ]] , aldosterone in observation group were significantly lower than those of control group, yet the LVEF was significantly higher than that of control group, with statistically significant difference （P 〈 0. 05 ）. CONCLUSIONS： Perindopril combined with spironolaetone in treatment of chronic heart failure can effectively inhibit activation of neuroendocrine system, reduce myocardial cell injury and ventricular remodeling, and promote to the facilitate prognosis.
作者
徐会玲
董良璞
XU Hulling DONG Liangpu(Dept. of Internal Medicine, Henan Tongbai County People＇s Hospital, Henan Tongbai 474750, Chin)
出处
《中国医院用药评价与分析》
2017年第4期494-496,共3页
Evaluation and Analysis of Drug-use in Hospitals of China
