摘要
目的:基于中医传承辅助平台(V2.5)软件,探讨中医经方治疗抑郁症的用药规律。方法:收集中国期刊全文数据库(CNKI),中文科技期刊数据库(VIP)和万方数据库发表的中医经方及其化裁治疗抑郁症的文献资料,时间设定为1986年1月至2016年12月,将所得数据规范完成后,输入中医传承辅助平台(V2.5)软件,建立数据库,运用中医传承辅助系统中的关联规则、改进的互信息法以及复杂系统熵聚类等无监督数据挖掘方法,分析治疗抑郁症经方中常用的药物、核心组合及发现新方。结果:筛选出符合条件的运用中医经方治疗抑郁症的发表文献共461篇,其中包含119首方剂,涉及中药155味,对其进行分析,发现方剂中出现有35味中药高频应用,频次前5位的中药为炙甘草、大枣、柴胡、半夏、白芍。通过关联规则挖掘出核心组合25个,通过聚类分析得到新方3个。结论:通过中医传承辅助平台(V2.5)对治疗抑郁症的中医经方进行分析,发现运用中医经方治疗抑郁症用药频次较高的中药,大多为辛甘温之品,归经于心、脾胃、肝、肾经的药物频率明显较高,其中尤以入心经为最多,这些高频中药大多有益气健脾、宁心安神、行气解郁的功效。经方治疗抑郁症注重通阳气、养心气、疏肝气、健脾气,为临床辨治抑郁症提供了参考。
Objective： To analyze medication regularity of traditional Chinese medicine（TCM） classical prescriptions for treating depression based on Traditional Chinese Medicine Inheritance Support System（TCMISS）.Method： Articles for classical prescriptions treatment for depressionin CNKI, VIP and Wanfang Datas from January 1986 to December 2016 were searched. The data was entered into TCMISS（V2. 5） to set up a database,andassociation rules and unsupervised hierarchical clustering were used to analyze common herbs and core combinations and find new prescriptions. Result： Totally 461 cases and 119 prescriptions were screened out,involving 155 herbs. Through analysis,totally 35 frequently used herbs were found,and the top five were Glycyrrhizae Radix et Rhizoma Praeparata Cum Melle,Jujubae Fructus,Bupleuri Radix,Pinelliae Rhizoma,Pinelliae Radix Alba. Totally 25 core combinations were mined through association rules, and three new prescriptions were mined through the cluster analysis from the database. Conclusion： Through TCMISS（V2. 5）,TCM classical prescriptionsin the treatment of depression were analyzed to find that frequently used TCM classical prescriptions for treating depression medication frequency are mostly pungent-sweet-warm herbs and those entering heart,spleen and liver and kidney meridians,especially those entering the heart channel. These frequently used TCMs mostly have an effect in replenishing Qi and tonifying spleen,calming nerves and replenishing vital energy,nourishing heart and relieving the depressed liver. Classical prescriptions for treating depression show an effect by activating Yang,nourishing the heart,disperse stagnated liver energy and replenishing spleen Qi,and can provide areference for clinical treatment of depression.
作者
邹锦
杨学琴
张小勇
王瑞婷
陶晓华
ZOU Jin YANG Xue-qin ZHANG Xiao-yong WANG Rui-ting TAO Xiao-hua(College of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, China)
出处
《中国实验方剂学杂志》
CAS
CSCD
北大核心
2017年第10期211-215,共5页
Chinese Journal of Experimental Traditional Medical Formulae
基金
北京中医药大学中青年教师面上项目(2015-JYB-JSMS049)
关键词
经方
抑郁症
关联规则
聚类算法
组方规律
classical prescription
depression
association rules
clustering algorithm
composition principle
