摘要
目的 研究马来酸依那普利叶酸片治疗H型高血压的临床疗效,并观察其对血同型半胱氨酸（Hcy）的影响,为临床诊疗提供依据.方法 选取126例H型高血压患者,根据随机数字表法将患者分为研究组和对照组,每组63例,对照组给予马来酸依那普利治疗,研究组给予马来酸依那普利叶酸片治疗,比较两组临床疗效,并观察治疗前和治疗后两组收缩压、舒张压和Hcy水平.结果 研究组总有效率90.5%（57/63）,对照组总有效率为74.6%（47/63）,两组差异有统计学意义（χ^2=15.371,P〈0.05）;两组治疗前收缩压和舒张压差异无统计学意义（P〉0.05）,治疗后研究组、对照组收缩压分别为（129.3±5.7）mmHg和（137.9±4.9）mmHg,舒张压为（81.5±3.6）mmHg和（89.6±5.1）mmHg,与治疗前比较差异均有统计学意义（t=8.969、7.851、7.343、6.987,均P〈0.05）,两组差异有统计学意义（P〈0.05）;治疗前两组Hcy比较差异无统计学意义（P〉0.05）,治疗后研究组、对照组Hcy分别为（8.93±0.63）μmol/L和（15.35±0.57）μmol/L,与治疗前比较差异有统计学意义（t=8.097、8.031,均P〈0.05）,两组比较差异有统计学意义（t=7.573,P〈0.05）.结论 马来酸依那普利叶酸片治疗H型高血压具有较好的临床效果,能明显降低血压,改善Hcy水平.
Objective To study the clinical effect of enalapril maleate and folic acid tablets in the treatment of H type hypertension, and to observe the blood homocysteine（Hcy）, to provide the basis for clinical diagnosis and treatment.Methods 126 patients with H type hypertension were selected.They were divided into study group and control group according to the random number table method,63 cases in each group.The control group was given enalapril maleate, the study group was given enalapril maleate and folic acid tablets.The clinical efficacy of the two groups was compared.The systolic blood pressure, diastolic blood pressure and Hcy level before and after treatment in two groups were observed.Results The total effective rate of the study group was 90.5%（57/63）,which of the control group was 74.6%（47/63）,the difference was statistically significant（χ^2=15.371,P〈0.05）.There was no significant difference in systolic blood pressure and diastolic blood pressure before treatment between the two groups（P〉0.05）.The systolic pressure after treatment of the two groups were （129.3±5.7）mmHg and （137.9±4.9）mmHg, the diastolic blood pressure were （81.5±3.6）mmHg and （89.6±5.1）mmHg, the differences were statistically significant compared with before treatment（t=8.969,7.851,7.343,6.987,all P〈0.05）,the difference between the two groups was statistically significant（P〈0.05）.There was no significant difference in Hcy before treatment between the two groups（P〉0.05）, after treatment Hcy levels of the two groups were （8.93±0.63）μmol/L and （15.35±0.57）μmol/L respectively, the differences were statistically significant compared with before treatment（t=8.097,8.031,all P〈0.05）,the difference between the two groups was statistically significant（t=7.573,P〈0.05）.Conclusion Enalapril maleate and folic acid tablets in the treatment of H type hypertension has good clinical effect, can significantly lower blood pressure, improve Hcy level.
出处
《中国基层医药》
CAS
2017年第10期1511-1514,共4页
Chinese Journal of Primary Medicine and Pharmacy
