摘要
目的:通过检测强直性脊柱炎患者骨组织中的碱性磷酸酶、抗酒石酸酸性磷酸酶的水平,探讨脊痹丸对强直性脊柱炎骨代谢的影响。方法:选取符合纳入标准的30例男性患者,予美洛昔康胶囊口服,脊痹丸口服。疗程为3个月。于治疗前后,分别检测患者血清骨碱性磷酸酶(BALP)和抗酒石酸酸性磷酸酶异构体(TRACP-5b)水平,采用酶联免疫吸附试验法(ELISA)检测。结果:TRACP-5b水平在治疗后降低,差异有统计学意义,而治疗前后的BALP水平差异无统计学意义。结论:TRACP-5b与骨吸收水平呈正相关,推测脊痹丸可以通过降低TRACP-5b水平抑制骨吸收,而发挥抗骨质疏松的作用。
Objective：To verify the serum levels of bone metabolic indices in patients with ankylosing spondylitis before and after Jibi pill treatment and detect effect of Jibi pill on bone metabolism in ankylosing spondylitis.Methods：30cases of male patients were diagnosed ankylosing spondylitis inpatients or outpatients,met the inclusion criteria and without any of the exclusion criteria.All cases were received treatment with meloxicam capsules and Jibi pill,and they were treated for 3months.Respectively analysing the serum levels of bone metabolic indices before and after treatment.The tartrate-resistant acid phosphatase isomer（TRACP-5b）serum levels and bone-specific alkaline phosphatase（BALP）serum levels were detected by enzymelinked immunosorbent assay（ELISA）method.Results：Compared before and after treatment,the serum levels of TRACP-5b were decreased（P〈0.05）.The serum levels of BALP had no significant difference（P〉0.05）.Conclusion：The reduction of TRACP-5bafter treatment suggests that Jibi pill can inhibit bone resorption and this relevants to anti osteoporosis.
作者
杨金连
郑宝林
Yang Jinlian Zheng Baolin(Department of Rheumatology, Affiliated Foshan Hospital, GuangZhou University of Traditional Chinese Medicine （Foshan 528000)
出处
《陕西中医》
2017年第5期592-593,共2页
Shaanxi Journal of Traditional Chinese Medicine
关键词
脊柱炎
强直性/中西医结合疗法
@脊痹丸
碱性磷酸酶
Spondylitis,ankylosing/integrated Chinese traditional and western medicine therapy
@Jibi pill
Alkaline phosphatase
