摘要
目的优选舒筋通络颗粒最佳矫味工艺和处方,并对其矫味效果进行综合评价。方法先采用正交实验对影响口味的乳香挥发油进行β-环糊精包合工艺优化,再采用模糊数学对处方中矫味剂的用量及工艺综合评价。结果乳香挥发油包合优化参数为:挥发油和β-环糊精的投料比为1∶8,包合温度为60℃,包合时间为180min;最佳矫味剂处方用量为0.015g·g^(-1)三氯蔗糖和0.01g·g^(-1) L-苹果酸。结论模糊数学可用于舒筋通络颗粒矫味工艺和处方的筛选,优化后的处方和工艺完全具备产业化生产条件,同时也符合相关法规要求。
Objective To optimize the process and prescription of Shujintongluo Granules,and to make a comprehensive evaluation on the effect of taste-modification.Methods By using orthogonal test,theβ-cyclodextrin inclusion process of Boswellia carterii volatile oil was optimized.Fuzzy mathematics was adopted to evaluate the prescription taste-modification dosage and process.Results The optimized parameters of theβ-cyclodextrin inclusion process of Boswellia carterii volatile oil were as follows：the ratio of Boswellia carterii volatile oil toβ-cyclodextrin was 1∶8,the inclusion temperature was 60 ℃,the inclusion time was 180min;the optimal prescription was 0.015g·g-1 sucralose,and 0.01g·g-1 L-malic acid.Conclusion The fuzzy mathematics can be used for the screening the taste-modification prescription in Shujintongluo Granules.Not only the optimized prescription and process could be applied under the industrial production conditions,but also meet the requirements of relevant laws and regulations.
出处
《西北药学杂志》
CAS
2017年第3期337-340,共4页
Northwest Pharmaceutical Journal
基金
石家庄市科学技术研究与发展计划项目(编号:20013A)
关键词
舒筋通络颗粒
Β-环糊精
矫味剂
模糊数学
正交实验
Shujintongluo Granules
β-cyclodextrin
taste-modification
fuzzy mathematics
orthogonal test
