摘要
目的:对硝西泮原料药中一种未知杂质进行结构确证。方法:应用HPLC-MS/MS、核磁共振(~1H-NMR、^(13)C-NMR)技术,对硝西泮原料药中一种未知杂质进行结构分析。结果:首次发现并确定硝西泮未知杂质的结构。结论:该方法可为硝西泮的质量控制提供依据。
Objective： To establish a method for the determination of the chemical structure of an unknown impurity in nitrazepam. Methods： HPLC-MS/MS and nuclear magnetic resonance（1H-NMR,13C-NMR） were adopted for determination of the chemical structure of an unknown impurity in nitrazepam. Results： The chemical structure of the unknown impurity was determined and identified. Conclusion： The established method can provide a complete solution for quality control of nitrazepam.
出处
《天津药学》
2017年第2期1-5,共5页
Tianjin Pharmacy
