期刊文献+

预防性应用头孢曲松钠对肝硬化上消化道出血患者感染的影响 被引量:13

Prophylactic application of ceftriaxone sodium in treatment of patients with liver cirrhosis com plicated by upper gastrointestinal bleeding
下载PDF
导出
摘要 目的探讨预防性应用头孢曲松钠对肝硬化并发上消化道出血患者感染的影响。方法在96例肝硬化并发上消化道出血患者,给予48例对照组常规止血和护肝治疗,48例观察组同时给予头孢曲松钠静脉滴注治疗。使用微生物分析仪行细菌培养与鉴定。结果治疗1 w后,观察组感染和再出血发生率分别为10.4%和18.8%,明显低于对照组(35.4%和41.7%,P<0.05),两组病死率无显著性差异(6.3%对10.4%,P>0.05);观察组感染发生率为10.4%,共分离出致病菌10株,对照组为35.4%,分离出33株;观察组外周血白细胞计数和C反应蛋白显著低于对照组(P<0.05)。结论预防性应用头孢曲松钠治疗肝硬化并发上消化道出血患者能降低医院感染发生率,减轻炎性反应。
出处 《实用肝脏病杂志》 CAS 2017年第3期362-363,共2页 Journal of Practical Hepatology
基金 四川省南充市科技局科研项目(编号:2015A0039)
关键词 肝硬化 上消化道出血 头孢曲松钠 感染 Liver cirrhosis Upper gastrointestinal bleeding Ceftriaxone sodium Infection
  • 相关文献

参考文献7

二级参考文献47

  • 1Salvador Augustin,Antonio González,Joan Genescà.Acute esophageal variceal bleeding:Current strategies and new perspectives[J].World Journal of Hepatology,2010,2(7):261-274. 被引量:44
  • 2中华医学会消化病学分会 中华医学会肝病学分会 中华医学会内镜学分会.肝硬化门静脉高压食管胃静脉曲张出血的防治共识[J].中华消化杂志,2008,:551-558.
  • 3Taneja SK, Dhiman RK. Prevention and management of bacterial infections in cirrhosis. Int J Hepato|,2011:78454i) Epuh 2011 Aug 28.
  • 4Almeida D, Lopes AA, Santos-Jesus R, et al. Comparative study of bacterial infection prevalence between cirrhotic patients with and without upper gastrointestinal bleeding. Braz J Infect Dis, 2001,5 : 136-142.
  • 5Montalto P, Vlachogiannakos J, Cox DJ, et al. Bacterial infection in cirrhosis impairs coagulation by a heparin effect a prospective study. J Hepatol, 2002,37:463-470.
  • 6Husova L, Lata J, Senkyrik M, et al. Bacterial infections in patients with acute hemorrhage due to port al hypertension personal experience. Vniter Lek, 2003,49 : 258-262.
  • 7Byl B, Roucloux I, Crusiaux A, Dupont E, Decidere J. Tumor necrosis factor alpha and interleukin 6 plasma levels in infected cirrhosis patients. Gastroenterology, 1993,104:1492-1497.
  • 8Bone RC, Grodzln CJ, Balk RA. Sepsis: a new hypothesis {or pathogenesis oI the disease process. Chest, 1997, 112:235-243.
  • 9Chavez-Tapia NC, Barrientos-Gutierrez T, et al. Antibiotic prophylaxis (or cirrhotic patients with upper gastrointestinal bleeding. Cochrane Database Syst Rev, 2010: CD002907.
  • 10European Association for the Study of liver. EASL clinical practice guidelines on the management of aseites, spontaneous bacterial peritonitis, and hepatorenal syndrome in cirrhosis. J Hepatol, 2010,53 : 397-4l 7.

共引文献804

同被引文献79

引证文献13

二级引证文献54

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部