摘要
目的:探讨小儿病毒性上呼吸道感染采用小儿豉翘清热颗粒治疗疗效。方法:截选2015年1月—2016年1月86例小儿病毒性上呼吸道感染患者按照随机数字表法分组为对照组[利巴韦林颗粒,10 mg/(kg·d),分2~3次服用]与治疗组(小儿豉翘清热颗粒,6个月~1岁,1~2 g/次,1~3岁,2~3 g/次,3~7岁,3~4 g/次;均为3次/d),各43例。记录两组患儿开始退热时间、完全退热时间,统计两组临床疗效及不良反应,并评价两组患儿治疗前、后中医证候积分变化;检测两组患儿治疗前、后血清肿瘤坏死因子α(TNF-α)、白细胞介素-6(IL-6)水平。结果:治疗组患儿开始退热时间、完全退热时间分别为(5.49±4.13)h、(9.20±3.75)h明显短于对照组(22.14±8.67)h、(25.48±12.25)h,P<0.05;两组患儿治疗后血清TNF-α、IL-6水平及中医证候积分明显低于治疗前,治疗组治疗后血清TNF-α、IL-6水平及中医证候积分明显低于对照组,P<0.05。治疗组治疗总有效率86.05%,明显高于对照组58.14%,P<0.05。治疗期间均无严重性不良反应,未影响本次研究结果。结论:采用小儿豉翘清热颗粒治疗小儿病毒性上呼吸道感染疗效显著且安全,可推荐为患儿治疗首选药物。
Objective-To explore the Xiaoer Chiqiao Qingre Granules treatment of children with viral infection of upper respiratory tract. Methods ： All patients according to the random number table method were divided into control group [ ribavirin granules, 10 mg/（kg ~ d）, divided into 2 -3 timesI and the treatment group（Xiaoer Chiqiao Qingre Gran- ules ,6 month - 1 year old, 1 - 2 g/time ; 1 to 3 years old, 2 - 3 g/time ;3 - 7 years old, 3 - 4 g/time ,3 times/d） ,43 eases in each. The two groups＇ fever relieving time and completed relieving time were recorded and the two groups＇ clinical efficacy and adverse reactions and TCM syndrome integral changes were evaluated of two groups before and after treat- ment. Detect two groups＇ Tumor necrosis factor - ot （ TNF - ct） and interleukin - 6 （ IL - 6） of children before and after treatment. Results： Treatment group＇ s fever relieving time and completed relieving time were respectively （5.49 ± 4.13 ） h, （9.20±3.75） h,significantly shorter than the control gruup＇ s （22.14±8.67） h and （25.48 ± 12.25） h, P 〈 0. 05. The two groups＇ serum levels of TNF - α, IL - 6 and TCM syndrome score after treatment were significantly lower than those before treatment. The treatment group ＇ s serum level of TNF - α, IL - 6 and TCM syndrome score after treat- ment were significantly lower than the control group＇s （P 〈 0. 05）. Treatment group＇s total effectiveness was 86.05% , obviously higher than the control group＇s 58.14% , P 〈0.05. During treatment there was no adverse reaction. Conclu- sion ： Xiaoer Chiqiao Qingre Granules have a good effect in treatment of infantile viral upper respiratory tract infection and can recommend the preferred drug for children with treatment.
出处
《中华中医药学刊》
CAS
北大核心
2017年第5期1330-1332,共3页
Chinese Archives of Traditional Chinese Medicine
关键词
小儿豉翘清热颗粒
小儿病毒性上呼吸道感染
利巴韦林颗粒
退热
血清指标
Xiaoer Chiqiao Qingre Granules
infantile viral upper respiratory tract infection
Ribavirin Granules
fe- ver
serum index
