摘要
目的优化白内障药物法可林1的合成工艺,以用于工业化生产。方法以O-苯二胺为起始原料,经缩合反应、磺化反应制得目标产物法可林1。结果对反应物配比、催化剂选择、反应温度及时间等因素进行了优化研究,使得该合成反应条件温和,后处理简单,总收率达40.7%,文献收率为24.8%。结论结构经~1H-NMR、MS确证,优化后的工艺更适合工业化生产。
Objectve To optimize the synthesis process of phacolysin 1 for industrial production.Methods Phacolysin as the target product was synthesized with a total yield of 40.7% by condensation reaction of O-phenylenediamine and sulfonation reaction.The yield reported in literature was 24.8%.Results Such factors as the ratio of the raw materials,the catalyst,and the reaction time were inveatigated and optimized to make the reaction conditions mild and easy to control with less side effect.Conclusion The structure is confirmed by 1HNMR and MS,and the optimized process is more suitable for industrial production.
出处
《军事医学》
CSCD
北大核心
2017年第4期291-294,共4页
Military Medical Sciences
关键词
法可林
眼药水
白内障
工艺学
制药
色谱法
高压液相
合成
phacolysin
ophthalmis solutions
cataract
technology
pharmaceutical
chromatography
high pressure liquid
synthesis
