摘要
目的:观察SonoVue关节腔内超声造影对正常兔膝关节滑膜及软骨的生物学效应。方法:将21只新西兰健康大白兔分为7组(每组3只,6个膝关节),其中1组为不进行造影的正常对照组。分别在造影后1、2、7、14、30、60 d处死兔子,取关节滑膜组织及软骨行HE染色,与正常组对照观察兔关节滑膜及软骨有无损伤。结果:滑膜及软骨细胞形态正常,未见肿胀变形,周围组织结构排列整齐。结论:SonoVue关节腔内超声造影安全可行。
Objective: To evaluate the histological alterations in rabbit knee joint synovial membrane and cartilage induced by intra-articular injections of contrast media SonoVue. Methods: Twenty one rabbits (42 knees) were divided into 7 groups (each with 3 rabbits 6 knees). We injected the knees with dilute SonoVue of 6 groups, and normal rabbit knee joint were used for comparison. A histological examination of the knees was carried out 1,2, 7, 14, 30 and 60 days after the injection. Results: On histological examination, synovial membrane cell and cartilage cell had normal morphology, synovial membrane was not swelling. Conclusion: The results suggest that intra- articular injection of SonoVue is a safe procedure.
作者
高慧
殷立平
徐大华
徐华宁
张芹
宋旭光
陆倩
GAO Hui YIN Li- ping XU Da- hua XU Hua- ning ZHANG Qin SONG Xu- guang LU Qian(Department of Ultrasound, the Traditional Chinese Medicine Hospital of Jiangsu Province, Nanjing University of Chinese Medicine, Nanfing 210029, China)
出处
《现代医学》
2017年第2期281-284,共4页
Modern Medical Journal
关键词
SONOVUE
造影剂效应
病理
关节
滑膜
关节软骨
兔
SonoVue
contrast media effects
histology
knees
synovium
articular cartilage
rabbits