摘要
目的观察还原型谷胱甘肽治疗非酒精性脂肪性肝炎(NASH)患者的疗效,并探讨其对患者血清白介素-6(IL-6)的影响。方法选取2014年1月至2016年1月清远市人民医院消化科收治的68例NASH患者,按照随机数字生成器将患者分为对照组和观察组,每组34例。对照组给予多烯磷脂酰胆碱、肌酐片和五酯胶囊治疗,观察组在对照组治疗的基础上给予还原型谷胱甘肽辅助治疗,连续治疗3个月。检测并比较两组治疗前后患者的血清谷丙转氨酶(ALT)、谷草转氨酶(AST)、IL-6的浓度水平,彩色多普勒检查患者肝胆胰脾情况。随访3个月,观察两组患者的治疗效果和复发情况。结果观察组患者的治疗总有效率为91.18%,显效率为38.24%,均明显高于对照组的70.59%和11.76%,差异均有统计学意义(P<0.05);两组患者治疗前的ALT与AST水平比较,差异均无统计学意义(P>0.05),治疗后,观察组患者的ALT与AST水平明显低于对照组,差异均有统计学意义(P<0.05);两组患者治疗前的IL-6水平比较差异均无统计学意义(P>0.05),治疗后,观察组患者IL-6浓度水平明显低于对照组,差异有统计学意义(P<0.05);随访3个月,对照组复发8例(23.53%),观察组复发2例(5.88%),观察组复发率明显低于对照组,差异有显著统计学意义(P<0.01)。结论还原型谷胱甘肽能够辅助治疗非酒精性脂肪性肝炎,其不仅可以降低ALT与AST水平,还可以减少患者血清促炎因子IL-6的水平,具有显著的增效作用,其机制可能与调节IL-6相关。
Objective To investigate the efficacy of reduced glutathione in the treatment of non-alcoholic ste- atohepatitis and its effect on the concentration of interleukin （IL）-6. Methods A total of 68 patients with non-alcoholic steatohepatitis, who admitted to Department of Gastroenterology of Qingyuan People Hospital from January 2014 to Jan- uary 2016, were selected and divided into the control group and treatment group by the random number generator, with 34 patients in each group. The patients in the control group were treated with the polyene phosphatidyl choline, creati- nine and wuzhi capsule. The patients in the treatment group were treated additionally with the reduced glutathione. All patients were continually treated for 3 months. The serum concentrations of alanine aminotransferase （ALT）, aspartate aminotransferase （AST）, IL-6 were tested and compared. Color Doppler ultrasound was used to check the hepatobil- lary-pancreatic-splenic disease. With a 3-rnonth follow-up, the reoccurrence rate was observed. Results The total effec- tive rate and obvious effective rate in the treatment group were respectively 91.18% and 38.24%, which were significant- ly higher than corresponding 70.59% and 11.76% in the control group （P〈0.05）. There was no difference between the two groups in the serum concentrations of ALT and AST before the treatment （P〉0.05）; after the treatment, the serum concentrations of ALT and AST in the treatment group were significantly lower than those in the control group （P〈0.05）. Furthermore, there was no difference between the two groups in the serum concentration of IL-6 before treatment （P〉 0.05）; after the therapy, the serum concentration of IL-6 in the treatment group was significantly lower than that in the control group （P〈0.05）. With the 3-month follow-up, the reoccurring rate of the treatment group was 5.88% （2 cases）, which was significantly lower than 23.53% （8 cases） of the control group （P〈0.01）. Conclusion Reduced glutathione has a very good adjuvant effect in the treatment of non-alcoholic steatohepatitis, which not only reduces the level of ALT and AST, but also reduces the level of serum proinflammatory cytokine IL-6. So the mechanism of that significant syner- gistic effect may be associated with the regulation of IL-6.
出处
《海南医学》
CAS
2017年第8期1242-1244,共3页
Hainan Medical Journal
