摘要
目的探讨丁苯酞软胶囊治疗脑卒中后轻度认知功能障碍的临床效果。方法 2016年1~12月,纳入符合研究条件的脑卒中后轻度认知功能障碍患者90例,用双盲法分为观察组和对照组,均给予基础治疗,观察组加丁苯酞软胶囊,对照组加吡拉西坦片,连续治疗14 d。比较两组治疗前后的血浆超氧化物歧化酶(SOD)水平、简易精神状态检查表(MMSE)评分、脑卒中神经功能缺损量表(CSS)评分、日常生活活动能力表(Barthel指数)评分;比较两组的疗效及不良反应。结果治疗后,观察组的血浆SOD上升且高于对照组,观察组的CSS评分较对照组低,Barthel、MMSE较对照组高;观察组的总有效率(93.33%)较对照组(80.00%)高(均P<0.05)。两组的不良反应发生率差异无统计学意义(P>0.05)。结论丁苯酞软胶囊能改善脑卒中后轻度认知功能障碍患者认知功能,可减轻神经功能缺损,提高日常生活能力,不良反应少,效果好,值得推广。
Objective To explore the clinical efficacy of Butylphthalide Soft Capsules in the treatment of mild cognitive impairment after stroke.Methods From January to December 2016,90 patients with mild cognitive impairment after stroke meeting the condition were included in the study.The patients were divided into observation group and control group by double-blind method.The patients were treated with basic therapy.The observation group was treated with Butylphthalide Soft Capsules.while the control group was treated by Piracetam and all patients were treated for 14 days. Plasma superoxide dismutase （SOD）,mini mental state examination （MMSE） score,China stroke scale （CSS） score,activities of daily living scale （Barthel index） before and after treatment between two groups were compared.Efficacy and ad- verse reactions were compared between the two groups.Results After treatment,the level of plasma SOD increased and higher than that of the control group,and CSS score in the observation group was lower than that of control group,and Barthel and MMSE score were higher than those in the control group and the total effective rate （93.33%） in the observation group was higher than that in the control group （80.00%） （P〈0.05）.There was no significant difference in the in cidence of adverse reactions between two groups（P〉0.05）.Conclusion Butylphthalide Soft Capsules can improve the cognitive function of patients with mild cognitive impairment after stroke,reduce neurological deficits,improve the daily living ability,less adverse reactions,the effect is good,and it is worthy of promotion.
作者
沈友进
王丹
万婷玉
任庆华
任志军
SHEN You-jin WANG Dan WAN Ting-yu REN Qing-hua REN Zhi-jun(Department of Neurology,Jiangmen People＇s Hospital in Guangdong Province,Jiangmen 529000,Chin)
出处
《中国当代医药》
2017年第13期48-50,共3页
China Modern Medicine
关键词
丁苯酞软胶囊
脑卒中
轻度认知功能障碍
Butylphthalide Soft Capsules
Stroke
Mild cognitive dysfunction
