摘要
目的探讨胃蛋白酶原(PG)、胃泌素-17(G-17)联合内镜筛查在早期胃癌诊断中的效果。方法选取2015年1~12月因上腹痛、反酸、嗳气等上消化道症状在本院就诊的门诊及住院的145例受检者,根据内镜活检及组织病理学检查分为正常组(n=30)、萎缩性胃炎组(n=28)、胃溃疡组(n=25)、早期胃癌组(n=32)及进展期胃癌组(n=30),检测血清PGⅠ、PGⅡ和G-17水平并探讨其在诊断胃癌中的价值。结果萎缩性胃炎组、早期胃癌组、进展期胃癌组的PGⅠ水平及PGR低于正常组,G-17水平高于正常组(P<0.05);萎缩性胃炎组、胃溃疡组的PGⅠ水平及PGR高于早期胃癌组,进展期胃癌组的PGⅠ水平及PGR低于早期胃癌组,进展期胃癌组的G-17水平高于早期胃癌组(P<0.05);胃癌组和非胃癌组血清PGⅠ、PGⅡ、PGR、G-17及联合检测的AUC均高于对照组(AUC=0.5)(P<0.05);两组四项联合检测的AUC均高于单项检测,且联合检测的特异度和灵敏度高于非胃癌组。结论PG、G-17联合内镜筛查有助于提高胃癌的早期诊断率,值得临床推广应用。
Objective To investigate the effect of pepsinogen （PG） and gastrin -17 （G-17） combined with endoscopic screening in the diagnosis of early gastric cancer.Methods From January 2015 to December 2015,145 outpatient and inpatient 145 subjects because of upper abdominal pain,belching and other symptoms of upper digestive tract in our hospital were selected and divided into the normal group （n=30）,the atrophic gastritis group （n=28）,the gastric ulcer group （n=25）,the early gastric cancer group （n=32） and the advanced gastric cancer group （n=30） according to endoscopic biopsy and histopathological examination.The levels of serum PG I ,PG 11 and G-17 were detected,and their value in the diagnosis of gastric cancer was discussed.Results The levels of PG I and PGR in the atrophic gastritis group,the early gastric cancer group and the advanced gastric cancer group was lower than that in the normal group,the G-17 level was higher than in the normal group （P〈0.05）.The levels of PG I and PGR in the atrophic gastritis group and the gastric ulcer group was higher than that in the early gastric cancer group,the levels of PG I and PGR in the advanced gastric cancer group was lower than that in the early gastric cancer group,the level of G-17 in the advanced gastric cancer group was higher than that in the early gastric cancer group （P〈0.05）.The A UC of PG I ,PG 11 ,PGR,G-17 and joint detection in the gastric cancer group and the non-gastric cancer group was significantly higher than that in the control group （A UC= 0.5） （P〈O.05）.Four groups of joint detection of A UC was higher than that in the single detection,the specificity and sen- sitivity of joint detection was higher than that in the non-gastric cancer group.Conclusion The PG I ,G-17 combined with endoscopic screening is help to improve the early diagnosis rate of gastric cancer, it is worthy of clinical promotion and application.
作者
谢俊锋
吴小娟
谢宁生
汤建华
XIE Jun-feng WU Xiao-juan XIE Ning-sheng TANG Jian-hua Department of Gastroenterology People＇s Hospital of Ganzhou City in Jiangxi Province Ganzhou 341000 China
出处
《中国当代医药》
2017年第13期81-83,共3页
China Modern Medicine
基金
江西省赣州市指导性科技计划项目(GZ2015ZSF163)
