摘要
磷脂酰肌醇蛋白聚糖-3(glypican-3,GPC-3)属于磷脂酰肌醇蛋白聚糖家族,其在肝细胞癌细胞膜表面、肝细胞癌患者血清中高表达,并在肝细胞癌的发生发展中发挥重要作用。针对GPC-3蛋白的靶向治疗,包括靶抗体、肽段疫苗、基因治疗(miRNA、shRNA、siRNA)等可特异性杀伤肝癌细胞,抑制肝细胞癌生长。本文将对GPC-3分子结构、其在肝细胞癌中的诊断价值、作用机制及其在肝细胞癌靶向治疗中的应用进行综述。
Glypican-3 belongs to the glypican family,and it has been identified as diagnostic molecule in hepatocellular carcinoma（HCC） due to its high expression in HCC cells and patients＇ serum. Additionally,data indicate that it plays an important role in the initiation and progression of HCC. Nowadays,GPC-3-targeted therapies,including antibodies,peptide vaccines,and genetic therapies（miRNA,shRNA,and siRNA） can inhibit tumor growth. In this review,we will summarize the molecular structure of GPC-3,and its role in pathogenesis,diagnosis,and targeted therapies in HCC and make further exploration of clinical implications of GPC-3 in HCC.
出处
《解放军医学院学报》
CAS
2017年第4期354-356,共3页
Academic Journal of Chinese PLA Medical School
基金
国家自然科学基金项目(81471683)~~
